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1-Piperidinecarboxylic acid, 3-(aMinocarbonyl)-, 1,1-diMethylethyl ester, (3R)-, commonly known as (3R)-baclofen, is a chemical compound derived from the neurotransmitter gamma-aminobutyric acid (GABA). It functions as a GABAB receptor agonist and is characterized by its ability to act as a skeletal muscle relaxant and antispastic agent. This property makes it a valuable asset in the treatment of various conditions that involve muscle spasms and spasticity.

170164-46-2

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170164-46-2 Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidinecarboxylic acid, 3-(aMinocarbonyl)-, 1,1-diMethylethyl ester, (3R)is used as a therapeutic agent for the management of muscle spasms and spasticity. It is particularly effective in treating conditions such as multiple sclerosis, spinal cord injuries, and cerebral palsy. The application reason for (3R)-baclofen in this context is its ability to reduce the transmission of signals from the nerves to the muscles, leading to a state of muscle relaxation and decreased rigidity.
The administration of (3R)-baclofen can be done through oral intake or via an intrathecal pump, depending on the severity and specific needs of the patient. Its mechanism of action involves mimicking the effects of GABA, a key inhibitory neurotransmitter in the central nervous system, thus helping to alleviate the symptoms associated with spasticity and muscle spasms.

Check Digit Verification of cas no

The CAS Registry Mumber 170164-46-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,1,6 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 170164-46:
(8*1)+(7*7)+(6*0)+(5*1)+(4*6)+(3*4)+(2*4)+(1*6)=112
112 % 10 = 2
So 170164-46-2 is a valid CAS Registry Number.

170164-46-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (3R)-3-carbamoylpiperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names (R)-tert-Butyl 3-carbamoylpiperazine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:170164-46-2 SDS

170164-46-2Relevant academic research and scientific papers

Kinetic resolution of piperazine-2-carboxamide by leucine aminopeptidase. An application in the synthesis of the nucleoside transport blocker (-)draflazine

Bruce,St. Laurent,Poindexter,Monkovic,Huang,Balasubramanian

, p. 2673 - 2684 (1995)

The resolution of N-t-Boc-piperazine carboxamide 5 proceeded smoothly in the presence of leucine aminopeptidase to produce acid (S)-1 and amide (R)-5 with good optical purity. Sequential alkylation and functional group manipulation of carboxamide (S)-5 provided the known nucleoside transport blocker (-)draflazine 2.

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