166520-13-4

Upstream product

• 683-57-8 bromo-acetic acid amide 
• 112257-24-6 tert-butyl 3-(aminocarbonyl)piperazine-1-carboxylate 
• 159572-93-7 (S)-(-)-Piperazine-2-carboxamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 170164-46-2 3R-(-)-1,1-dimethylethyl 3-aminocarbonyl-1-piperazinecarboxylate 
• 170164-47-3 3S-(+)-1,1-dimethylethyl 3-aminocarbonyl-1-piperazinecarboxylate 

Relevant academic research and scientific papers

Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles

A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective antiischemic protection for CNS and cardiac tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma, stroke, or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.

Kinetic resolution of piperazine-2-carboxamide by leucine aminopeptidase. An application in the synthesis of the nucleoside transport blocker (-)draflazine

The resolution of N-t-Boc-piperazine carboxamide 5 proceeded smoothly in the presence of leucine aminopeptidase to produce acid (S)-1 and amide (R)-5 with good optical purity. Sequential alkylation and functional group manipulation of carboxamide (S)-5 provided the known nucleoside transport blocker (-)draflazine 2.