17018-81-4Relevant academic research and scientific papers
Tracking the Progress and Mechanism Study of a Solvothermal in Situ Domino N-Alkylation Reaction of Triethylamine and Ammonia Assisted by Ferrous Sulfate
Zhong, Jin-Ping,Liu, Bin,Yang, Tao,Liu, Yue-Jin,Zhu, Zhong-Hong,Shi, Bing-Feng,Kurmoo, Mohamedally,Zeng, Ming-Hua
, p. 10123 - 10126 (2017)
Atom economic in situ domino N-alkylation reactions of triethylamine/ammonia with 2-(hydroxymethyl)quinolin-8-ol (HL-OH) assisted by FeSO4·7H2O were realized under mild solvothermal conditions at 120 °C in acetonitrile. The resulting tripodal 2,2′,2″-[nitrilotris(methylene)]tris(quinolin-8-ol) (H3L3-N) forms a linear trimer [Fe3(L3-N)2] (1). Electrospray ionization mass spectrometry of the reaction solution provides evidence for the intermediates of three steps, while crystallography and X-ray photoelectron spectroscopy characterize the trimer. Shortening the time of the reaction allowed for the organic intermediates to be isolated, which led to a proposed mechanism. The method provides a facile way to produce symmetric tertiary amine from widely used NEt3 and NH3. The results represent an example of the in situ Fe2+-catalyzed domino reaction in which Fe2+ is coordinated by the generated ligands and is involved in each step until the final cluster 1.
Highly stable and soluble bis-aqua Gd, Nd, Yb complexes as potential bimodal MRI/NIR imaging agents
Tallec, Gaylord,Imbert, Daniel,Fries, Pascal H.,Mazzanti, Marinella
supporting information; experimental part, p. 9490 - 9492 (2011/01/10)
A tripodal ligand based on the 8-hydroxyquinolinate binding unit yields a soluble and highly stable bis-hydrated Gd3+ complex in water (pGd = 19.2(3)) with relaxivity change in the pH range 4.5-7.4 and Nd3+, Yb3+ analogues with sizeable NIR emission upon excitation at 370 nm providing a new architecture for the development of bimodal agents.
Heterocyclic amines for the construction of peptoid oligomers bearing multi-dentate ligands
Maayan, Galia,Yoo, Barney,Kirshenbaum, Kent
, p. 335 - 338 (2008/09/17)
Peptoids are oligomers of N-substituted glycine that can be readily assembled using haloacetic acids and primary amines as synthons. Here, we report the synthesis and characterization of three new heterocyclic amines, 2-(2,2′:6′,2″-terpyridine-4′-yloxy)ethylamine, 2-(1,10-phenanthroline-5-yloxy)ethylamine and 8-hydroxy-2-quinolinemethylamine, and their incorporation into a series of different peptoid oligomer sequences. Since the heterocycles are all known to coordinate metal ions, the peptidomimetic products are designed to bind metal species with the potential for applications in catalysis and materials science.
8-HYDROXY QUINOLINE DERIVATIVES
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Page 39, (2008/06/13)
The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to
