170210-54-5Relevant academic research and scientific papers
Synthesis of azepane scaffolds on solid support for combinatorial chemistry
Gauzy, Laurence,Merrer, Yves Le,Depezay, Jean-Claude,Clerc, Francois,Mignani, Serge
, p. 6005 - 6008 (1999)
Enantiopure C2-symmetric azepanes have been synthesized on solid support as scaffolds for the synthesis of peptidomimetics in combinatorial chemistry. The key step involves Rink resin as a formal equivalent of ammonia in the nucleophilic opening of L-iditol bis-epoxide.
Seven-membered ring azasugars as glycosidase inhibitors and anticancer agents
Lohray,Bhushan, Vidya,Prasuna,Jayamma,Raheem,Papireddy,Umadevi,Premkumar,Lakshmi,Narayanareddy
, p. 1311 - 1321 (2007/10/03)
Synthesis of various C2 symmetrical tetrahydroxyazepanes has been reported by the reaction of bisepoxides with various primary, amines. The tetrahydroxyazepanes inhibit β-glucosidases in micromolar range and also exhibit anticancer activity in
