170219-85-9Relevant academic research and scientific papers
NON-PEPTIDE PEPTIDOMIMETICS
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, (2008/06/13)
Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: STR1 wherein at least one of R 1, R 2, R. sub.3, R. sub.4, or R 5 comprises a functional group which is chemically similar to that found in the peptide of interest.
De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing β-D-glucose as a novel scaffolding
Hirschmann, Ralph,Nicolaou,Pietranico, Sherrie,Leahy, Ellen M.,Salvino, Joseph,Arison, Byron,Cichy, Maria A.,Grant Spoors,Shakespeare, William C.,Sprengeler, Paul A.,Hamley, Peter,Smith III, Amos B.,Reisine, Terry,Raynor, Karen,Maechler, Laurie,Donaldson, Cindy,Vale, Wylie,Freidinger, Roger M.,Cascieri, Margaret R.,Strader, Catherine D.
, p. 12550 - 12568 (2007/10/02)
Non-peptide peptidomimetics of the peptide hormone somatostatin (SRIF) were designed and synthesized, utilizing β-D-glucose as a novel scaffolding. Such compounds resemble conventional peptide analogs in that they retain critical amino acid side chains bu
