170232-68-5

Basic information

• Product Name: 2,4-Dibromothiazole-5-methanol
• Synonyms: 2,4-Dibromothiazole-5-methanol;(dibroMo-1,3-thiazol-5-yl)Methanol
• CAS NO: 170232-68-5
• Molecular Formula: C₄H₃Br₂NOS
• Molecular Weight: 272.96
• Mol File: 170232-68-5.mol

Chemical Properties

• Boiling Point: 349.042 °C at 760 mmHg
• Flash Point: 164.895 °C
• Appearance: /
• Density: 2.307g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.50±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dibromothiazole-5-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dibromothiazole-5-methanol(170232-68-5)
• EPA Substance Registry System: 2,4-Dibromothiazole-5-methanol(170232-68-5)

Safety Data

• Hazardous Substances Data: 170232-68-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4-Dibromothiazole-5-methanol is used as a key intermediate in the synthesis of various complex organic compounds. Its unique structure, which includes a thiazole ring and a methanol group, allows it to participate in a range of chemical reactions, making it a valuable building block in the creation of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4-Dibromothiazole-5-methanol is used as a starting material for the development of new drugs. Its reactivity and structural features enable the creation of novel drug candidates that could potentially address unmet medical needs or improve upon existing treatments.
Used in Chemical Research:
2,4-Dibromothiazole-5-methanol is also used as a research tool in academic and industrial laboratories. Its properties and reactivity make it an interesting subject for studies aimed at understanding the behavior of complex organic molecules and developing new synthetic strategies.
Used in Material Science:
In the field of material science, 2,4-Dibromothiazole-5-methanol is used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with improved characteristics, such as enhanced stability, reactivity, or selectivity.

InChI:InChI=1/C4H3Br2NOS/c5-3-2(1-8)9-4(6)7-3/h8H,1H2

Upstream product

• 918164-43-9 methyl 2,4-dibromothiazole-5-carboxylate 
• 139669-95-7 2,4-dibromo-1,3-thiazole-5-carbaldehyde 

Downstream Products

• 38585-74-9 thiazol-5-yl-methanol 
• 873066-26-3 [4-bromo-2-(4-trifluoromethylphenyl)thiazol-5-yl]methanol 
• 262444-15-5 (4-bromo-1,3-thiazol-5-yl)methanol 
• 918164-49-5 PdBr(P(C₆H₅)3)2C₄HS(COOCH₂CH₃)(C₆H₄CF₃) 
• 918164-48-4 PdBr(P(C₆H₅)3)2C₃NSBrCH₂OH 

Relevant articles and documents

2-(1-HETEROARYLPIPERAZIN-4-YL)METHYL-1,4-BENZODIOXANE DERIVATIVES AS ALPHA2C ANTAGONISTS

Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the treatment of diseases or conditions of the peripheric or central nervous system.

Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/ dibromothiazoles and arylboronic acids. Synthesis of PPARβ/δ agonists

A reactivity study, aided by NMR spectroscopy, allowed a mechanistic rationale to be postulated for the palladium-catalyzed regioselective coupling of arylboronic acid (and arylstannane where feasible) at the position next to the sulfur atom in functional

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Pyrrolopyrimidines as therapeutic agents

Chemical compounds having structural formula I and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatiod arthritis, disorders of the immune system, trasplant refections and imflammatory disorders.

A novel and efficient synthesis of 5-(hydroxymethyl)thiazole: An important synthon for preparing biologically active compounds

A novel and efficient synthesis of 5-(hydroxymethyl)thiazole, an important synthon for the preparation of biologically active compounds, is described. The research also provides additional insight into the properties of halothiazoles.