170236-11-0Relevant academic research and scientific papers
Synthesis of a potential enzyme-specific inhibitor of squalene synthase
Valentijn, A. R. P. M.,Haan, R. de,Hagens, S.,Kant, E. de,Marel, G. A. van der,et al.
, p. 332 - 336 (2007/10/02)
A multi-step synthesis of phosphinylphosphonate analogue 12 of the proposed farnesyl-farnesyl-enzyme (FFE) intermediate in the enzymatic conversion of farnesyl pyrophosphate to squalene is described.In addition, evidence is presented of the inhibitory effect of 12 on squalene synthase.
