170236-39-2Relevant articles and documents
MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF
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, (2021/02/19)
The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside. An oligomeric compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides, wherein at least one nucleoside of the modified oligonucleotide is a stereo-non-standard nucleoside; and wherein the oligomeric compound is selected from among an RNAi compound, a modified CRISPR compound, and an artificial mRNA compound.
DNA with 3′-5′-disulfide links - Rapid chemical ligation through isosteric replacement
Patzke, Volker,McCaskill, John S.,Von Kiedrowski, Guenter
, p. 4222 - 4226 (2014/05/06)
Efforts to chemically ligate oligonucleotides, without resorting to biochemical enzymes, have led to a multitude of synthetic analogues, and have extended oligomer ligation to reactions of novel oligonucleotides, peptides, and hybrids such as PNA.1 Key re
COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
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Page/Page column 35, (2011/04/25)
The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.