170236-39-2

Upstream product

• 825638-98-0 C₃₅H₃₅N₅O₇ 
• 104769-15-5 [(2R,3S,5R)-3-hydroxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]tetrahydrofuran-2-yl]methyl benzoate 
• 121513-00-6 [(2R,3R,5R)-2-(hydroxymethyl)-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate 
• 170236-40-5 5'-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3'-O-benzoyl-2'-desoxyxyloguanosine 
• 121513-00-6 3-O-benzoyl-2-desoxyxyloguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 170236-40-5 [(2R,3R,5R)-2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo- 1H-purin-9-yl]tetrahydrofuran-3-yl] benzoate 
• 1187644-19-4 3'-O(R)-(methylsulfonyl)-N₂-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine 
• 961-07-9 2'-Deoxyguanosine 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 
• 68892-42-2 N-isobutyryl-2'-deoxyguanosine 
• 118-00-3 G 
• 87865-78-9 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine 
• 64350-24-9 N²-isobutyryl-2'-deoxyguanosine 

Downstream Products

• 170236-41-6 3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine 
• 934980-57-1 N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine 
• 1421632-81-6 N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thioguanosine 
• 1421632-82-7 N₂-isobutyryl-5'-O-dimethoxytrityl-2'-deoxy-3'-thio-guanosine-3'-S-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite 
• 1609117-77-2 3-S-acetyl-5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine 
• 1421632-81-6 5-O-(4,4-dimethoxytriphenyl)methyl-N-2-isobutyryl-3-thio-2-3-didesoxyguanosine 

Relevant academic research and scientific papers

MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside. An oligomeric compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides, wherein at least one nucleoside of the modified oligonucleotide is a stereo-non-standard nucleoside; and wherein the oligomeric compound is selected from among an RNAi compound, a modified CRISPR compound, and an artificial mRNA compound.

MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF

The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside.

DNA with 3′-5′-disulfide links - Rapid chemical ligation through isosteric replacement

Efforts to chemically ligate oligonucleotides, without resorting to biochemical enzymes, have led to a multitude of synthetic analogues, and have extended oligomer ligation to reactions of novel oligonucleotides, peptides, and hybrids such as PNA.1 Key re

Thermal stabilisation of RNA·RNA duplexes and G-quadruplexes by phosphorothiolate linkages

The effect of 3′-S-phosphorothiolate linkages on the stability of RNA·RNA duplexes and G-quadruplex structures has been studied. 3′-Thio-2′-deoxyuridine was incorporated into RNA duplexes and thermal melting studies revealed that the resulting 3′-S-phosph

COMPOUNDS FOR TREATING BACTERIAL INFECTIONS

The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.

Improved and Reliable Synthesis of 3′-Azido-2′,3′ -dideoxyguanosine Derivatives

An improved synthesis of N2-protected-3′-azido-2′ ,3′-dideoxyguinosine 20 and 23 is described. Deoxygenation of 2′-O-alkyl (and/or aryl) sulfonyl-5′-dimethoxytritylguanosine coupled with [1,2]-hydride shift rearrangement gave protected 9-(2-deoxythreo-pentofuranosyl)guanines (10, 12 and 16). This rearrangement was accomplished in high yield with a high degree of stereoselectivity using lithium triisobutylborohydride (L-Selectride R). Compounds 10, 12 and 16 were transformed into 3′-O-mesylates (18 and 21), which can be used for 3′-substitution. The 3′-azido nucleosides were obtained by treatment of 18 and 21 with lithium azide. This procedure is reproducible with a good overall yield.