170240-80-9

Upstream product

• 170240-79-6 (4R)-(2-methoxy-4-methylphenyl)pentyl acetate 
• 164921-78-2 (E)-5-Acetoxy-4-(2-methoxy-4-methyl-phenyl)-pent-2-enoic acid methyl ester 
• 170423-80-0 (4R)-(2-methoxy-4-methylphenyl)pentanol 
• 170423-77-5 (R)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester 
• 170423-69-5 methyl (4R)-(2-methoxy-4-methylphenyl)-5-hydroxyphenoate 
• 170423-67-3 (E)-(R)-5-Acetoxy-4-(2-methoxy-4-methyl-phenyl)-pent-2-enoic acid methyl ester 
• 170423-78-6 methyl (4R)-(2-methoxy-4-methylphenyl)-5-tosyloxypentanoate 
• 164921-74-8 methyl 4-(2'-methoxy-4'-methylphenyl)-5-hydroxy-(2E)-pentanoate 

Downstream Products

• 170240-81-0 (4R)-(2-methoxymethyloxy-4-methylphenyl)pentyl acetate 
• 17194-58-0 2-[(1R)-1,5-dimethylhex-4-enyl]-5-methylphenol 
• 170240-82-1 (4R)-(2-methoxymethyloxy-4-methylphenyl)pentanol 
• 170240-83-2 (R)-4-(2-Methoxymethoxy-4-methyl-phenyl)-pentanal 
• 170240-84-3 1-((R)-1,5-Dimethyl-hex-4-enyl)-2-methoxymethoxy-4-methyl-benzene 

Relevant academic research and scientific papers

Total synthesis of (S)-(+)-curcudiol, and (S)-(+)- and (R)-(-)-curcuphenol1)

A highly enantioselective synthesis of the versatile chiral synthons possessing one stereogenic center, (S)-and (R)-4-aryl-5-hydroxy-(2E)-pentenoate (3) was achieved based on the enzymatic reaction of (±)-3 with commercially available lipases MY-30 or OF-360 from Candida rugosa. Application of (S)-3 and (R)-3 to the total syntheses of (S)-curcuphenol (1), (S)-curcudiol (2), and (R)-curcuphenol (1), respectively, is described.

Total Synthesis of (S)-(+)-Curcudiol, (S)- and (R)-(-)-Curcuphenol Based on Enzymatic Resolution of a Primary Alcohol Possessing One Stereogenic Center

A highly stereoselective synthesis of the versatile chiral synthons possessing one stereogenic center, (S)-3 and (R)-3 was achieved and the application of (S)-3 and (R)-3 into the total syntheses of (S)-curcuphenol (1), (S)-curcudiol (2), and (R)-curcuphenol (1), respectively, was described.