170353-35-2

Basic information

• Product Name: (1-PHENYLPIPERIDIN-4-YL)METHANAMINE
• Synonyms: (1-PHENYLPIPERIDIN-4-YL)METHANAMINE
• CAS NO: 170353-35-2
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Mol File: 170353-35-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-PHENYLPIPERIDIN-4-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1-PHENYLPIPERIDIN-4-YL)METHANAMINE(170353-35-2)
• EPA Substance Registry System: (1-PHENYLPIPERIDIN-4-YL)METHANAMINE(170353-35-2)

Safety Data

• Hazardous Substances Data: 170353-35-2(Hazardous Substances Data)

Usage

Description

(1-PHENYLPIPERIDIN-4-YL)METHANAMINE, also known as 4-anilinopiperidine, is a psychoactive chemical compound with the molecular formula C13H18N2. It acts as a potent dopamine reuptake inhibitor and is often used in the synthesis of other pharmaceutical drugs, including certain stimulants and analgesics.
Used in Pharmaceutical Industry:
(1-PHENYLPIPERIDIN-4-YL)METHANAMINE is used as a precursor in the production of fentanyl and its analogs, which are potent opioid drugs. It is also used in the synthesis of other pharmaceutical drugs, including certain stimulants and analgesics, due to its potent dopamine reuptake inhibitory properties.
Used in Research and Development:
(1-PHENYLPIPERIDIN-4-YL)METHANAMINE is used as a research chemical for studying the effects of psychoactive substances on the central nervous system and their potential therapeutic applications.
Note: Due to its psychoactive properties and potential for misuse, (1-phenylpiperidin-4-yl)methanamine is classified as a controlled substance in many countries and is subject to strict regulations and controls.

Upstream product

• 1337606-81-1 C₁₂H₁₄N₂ 
• 19125-34-9 1-phenylpiperidin-4-one 
• 1453-82-3 isonicotinamide 

Downstream Products

• 1114065-77-8 3-(4-fluorophenyl)-1-((1-phenylpiperidin-4-yl)methylamino)hex-5-en-3-ol 
• 389601-71-2 N-(1-Phenyl-piperidin-4-yl-methyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 

Relevant articles and documents

COMPOUNDS AND METHODS OF THEIR USE

Provided are agents capable of binding the KIX domain of CBP or MED15 to inhibit the binding between SREBP1 and the KIX domain of MED15 or CBP. Also provided are compositions containing the agents and methods of their use.

N-substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as 92 antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents

A series of N-substituted 1-(2,3-dihydro-1,4-benzodioxin-2- yl)methylamine derivatives with D2 antagonist/5-HT(1A) partial agonist activity has been prepared as potential atypical antipsychotic agents. Optimization of in vitro receptor binding activity and in vivo activity in rodent models of psychosis has led to compound 24, which showed good affinities for human D2, D3, and 5-HT(1A) receptors but significantly less affinity for human α1 adrenoceptors and rat H1 and muscarinic receptors. In rodents, 24 showed functional D2-like antagonism and 5-HT(1A) partial agonism. After oral dosing, 24 showed good activity in rodent antipsychotic tests and very little potential to cause extrapyramidal side effects (EPS), as measured by its ability to induce catalepsy in rats only at very high doses. In the light of this promising profile of activity, 24 has been selected for clinical investigation as a novel antipsychotic agent with a predicted low propensity to cause EPS.