170379-52-9Relevant academic research and scientific papers
Pteridine nucleosides - New versatile building blocks in oligonucleotide synthesis
Charubala, Ramamurthy,Maurinsh, Juris,Roesier, Angelika,Melguizo, Manuel,Jungmann, Oliver,Gottlieb, Margarete,Lehbauer, Joerg,Hawkins, Mary,Pfleiderer, Wolfgang
, p. 1369 - 1378 (2007/10/03)
Chemical syntheses of 1-(2-deoxy-β-D-ribofuranosyl)lumazines and isoptefins as well as 8-(2-deoxy-β-D-ribofuranosyl)-4-amino-7(8H)pteridones and -isoxantho-pterins have been developed to make the structural analogs of the naturally occurring 2'-deoxyribonucleosides in the pteridine series available. The corresponding phosphoramidites have been used in machine- aided solid-support syntheses leading to new types of fluorescence labeled oligonucleotides. The effects of the various fluorophors on duplex formation and as labels for enzyme reactions is demonstrated.
