170464-80-9Relevant academic research and scientific papers
PYRROLOPYRIMIDIMES. I: Synthesis of Novel Pyrrolopyrimidine Derivatives With Antimicrobial Activity
El-Bayouki, Khairy A. M.,Basyouni, Wahid M.,Hosni, H.,El-Deen, A. Shehab
, p. 1901 - 1912 (2007/10/02)
The preparation and cyclization of 2-aminopyrrole-3-carbonitriles 3 to the corresponding pyrrolopyrimidin-4-ones 5 were carriedout.The products 5 with phosphoryl chloride gave 4-chloropyrrolopyrimidine derivatives 7, which when reacted with hydrazine hydrate gave the corresponding 4-hydrazinopyrrolopyrimidines 8 in excellent yield.The syntheses of triazolo-9, tetrazolo-10 and 4-(3,5-dimethylpyrazolo)-12 pyrrolopyrimidines, as well as of a 3-(pyrrolopyrimidynylhydrazono)butanoate ester 13, are also reported.Selected examples from the newly synthesized compounds were tested in vitro for their antimicrobial activity.
