170464-84-3

Upstream product

• 170464-78-5 2-amino-4-(4-fluorophenyl)-1-(p-tolyl)pyrrole-3-carboxamide 
• 170464-69-4 2-amino-4-(4-fluorophenyl)-1-(p-tolyl)pyrrole-3-carbonitrile 
• 146537-21-5 1-(4-fluorophenyl)-2-(p-tolylamino)ethanone 
• 204271-32-9 5-(4-Fluoro-phenyl)-4-imino-7-p-tolyl-4,7-dihydro-pyrrolo[2,3-d]pyrimidin-3-ylamine 
• 170464-82-1 4-chloro-5-(4-fluorophenyl)-7-(p-tolyl)-7H-pyrrolo<2,3-d>pyrimidine 

Downstream Products

• 204271-65-8 N-[5-(4-Fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N'-[1-thiophen-2-yl-meth-(E)-ylidene]-hydrazine 
• 204271-70-5 N-[5-(4-Fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N'-[1-furan-2-yl-eth-(E)-ylidene]-hydrazine 
• 204271-63-6 N-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-N'-[5-(4-fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 204271-67-0 N-[1-(4-Fluoro-phenyl)-eth-(E)-ylidene]-N'-[5-(4-fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 204271-69-2 N-[5-(4-Fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N'-[1-p-tolyl-eth-(E)-ylidene]-hydrazine 
• 204271-68-1 N-[5-(4-Fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-N'-[1-(4-methoxy-phenyl)-eth-(E)-ylidene]-hydrazine 

Relevant academic research and scientific papers

Pyrrolopyrimidines. Part 3 : Synthesis of Some Novel 4-Subsituted Pyrrolopyrimidines and Their Related Triazolo Derivatives.

3-Amino-5-aryl-4-imino-7-(p-tolyl)-4,7-dihydropyrrolo-3H-pyrimidines 3 were synthesized from reacting 2-ethoxymethylideneaminopyrrole-3-carbonitriles 2 with hydrazine hydrate.Rearrangement of 3 to 4-hydrazino-7H-pyrrolopyrimidines 4 was carried out.Products 3 were cyclized to the corresponding substituted 9-aryl-7-(p-tolyl)-7H-pyrrolotriazolopyrimidine derivatives 6-12 and 14 upon reacting with triethyl orthoformate, acetic acid, aldehydes, ethyl chloroformate, acyl chlorides and isothiocyanates respectively.The N-substituted-N'-pyrimidin-3-yl>ureas 13a-c and thioureas 13d-h were also obtained from reacting 3a with isocyanates and isothiocyanates respectively.Condensation of 4b with aldehydes and ketones afforded the hydrazones 15 in good yields. - Key words: Pyrrolopyrimidines; pyrrolotriazolo-pyrimidines.

PYRROLOPYRIMIDIMES. I: Synthesis of Novel Pyrrolopyrimidine Derivatives With Antimicrobial Activity

The preparation and cyclization of 2-aminopyrrole-3-carbonitriles 3 to the corresponding pyrrolopyrimidin-4-ones 5 were carriedout.The products 5 with phosphoryl chloride gave 4-chloropyrrolopyrimidine derivatives 7, which when reacted with hydrazine hydrate gave the corresponding 4-hydrazinopyrrolopyrimidines 8 in excellent yield.The syntheses of triazolo-9, tetrazolo-10 and 4-(3,5-dimethylpyrazolo)-12 pyrrolopyrimidines, as well as of a 3-(pyrrolopyrimidynylhydrazono)butanoate ester 13, are also reported.Selected examples from the newly synthesized compounds were tested in vitro for their antimicrobial activity.