204271-32-9

Upstream product

• 170464-69-4 2-amino-4-(4-fluorophenyl)-1-(p-tolyl)pyrrole-3-carbonitrile 
• 204271-30-7 N-[3-Cyano-4-(4-fluoro-phenyl)-1-p-tolyl-1H-pyrrol-2-yl]-formimidic acid ethyl ester 

Downstream Products

• 170464-84-3 [5-(4-Fluoro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 

Relevant academic research and scientific papers

Pyrrolopyrimidines. Part 3 : Synthesis of Some Novel 4-Subsituted Pyrrolopyrimidines and Their Related Triazolo Derivatives.

3-Amino-5-aryl-4-imino-7-(p-tolyl)-4,7-dihydropyrrolo-3H-pyrimidines 3 were synthesized from reacting 2-ethoxymethylideneaminopyrrole-3-carbonitriles 2 with hydrazine hydrate.Rearrangement of 3 to 4-hydrazino-7H-pyrrolopyrimidines 4 was carried out.Products 3 were cyclized to the corresponding substituted 9-aryl-7-(p-tolyl)-7H-pyrrolotriazolopyrimidine derivatives 6-12 and 14 upon reacting with triethyl orthoformate, acetic acid, aldehydes, ethyl chloroformate, acyl chlorides and isothiocyanates respectively.The N-substituted-N'-pyrimidin-3-yl>ureas 13a-c and thioureas 13d-h were also obtained from reacting 3a with isocyanates and isothiocyanates respectively.Condensation of 4b with aldehydes and ketones afforded the hydrazones 15 in good yields. - Key words: Pyrrolopyrimidines; pyrrolotriazolo-pyrimidines.