170489-91-5Relevant articles and documents
Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
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, (2008/06/13)
The invention relates to novel racemic or optically active aminopropanol derivatives of formula I STR1 wherein R and R 1 are independently hydrogen atom, halogen atom, lower alkoxy, or together represent a methylene dioxy group,R 2 and R 3 together represent a chemical bond or independently stand for a hydrogen atom,R 4 and R 5 are independently hydrogen atom, C 3-7 cycloalkyl group or straight or branched, saturated or unsaturated C 1-12 alkyl group optionally substituted by one or more dialkylaminoalkyl, dimethoxyphenyl or phenyl groups, orR 4 and R 5 together with the adjacent nitrogen atom form a 4 to 7 membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which ring is optionally substituted by a phenyl, benzyl or C 1-3 alkyl group and the said substituents may carry a hydroxyl group, one or two methoxy groups, halogen atoms or trifluoromethyl groups, orR 4 and R 5 together with the adjacent nitrogen atom form a piperidine ring which is optionally substituted by a phenyl or benzyl group and, if desired, it comprises a double bond,R 6 stands for hydrogen atom or benzoyl group, andn represents an integer from 3 to 6, acid-addition salts and quaternary ammonium derivatives thereof.Further the invention relates to processes for preparing these compounds.The compounds of the invention exert cardiac circulation controlling and/or improving, central nervous system tranquillizing and/or digestive system irregulations improving effects.
