17049-39-7Relevant academic research and scientific papers
Halogen-metal exchange in 1,2-dibromobenzene and the possible intermediacy of 1,2-dilithiobenzene
Bettinger, Holger F.,Filthaus, Matthias
, p. 9750 - 9752 (2007)
(Chemical Equation Presented) The one-step high-yield synthesis of 1,2-bis(trimethylsilyl)-benzene from 1,2-dibromobenzene using tert-butyllithium and trimethylsilyltriflate is reported. A mechanistic investigation shows that 1,2-dilithiobenzene is not an intermediate in this reaction; the coexistence of trimethylsilyltriflate and tert-butyllithium at very low temperatures allows a sequence of bromine-lithium exchange and subsequent derivatization reactions to operate.
