170510-32-4Relevant academic research and scientific papers
Outer-ring stereochemical modulation of cytotoxicity in cephalostatins.
LaCour,Guo,Boyd,Fuchs
, p. 33 - 36 (2007/10/03)
[structure: see text] 20- and 25'-epimers of cephalostatin 7, prepared by directed unsymmetrical pyrazine synthesis, address outer-ring topographical and stability questions and intimate an oxacarbenium ion rationale for the role in bioactivity of the spi
Synthesis of the north 1 unit of the cephalostatin family from hecogenin acetate 1
Kim, Seongkon,Sutton, Scott C.,Guo, Chuangxing,LaCour, Thomas G.,Fuchs
, p. 2056 - 2070 (2007/10/03)
Hecogenin acetate (1) was converted to North 1 azidoketone 5 involving several key transformations: (1) conversion of cyclic sulfate 33b to allylic alcohol 40 via Reich iodoso olefination; (2) E-ring annulation via intermolecular oxygen alkylation of high
