170573-91-8Relevant academic research and scientific papers
Synthesis and antifungal activity of new azole derivatives containing an oxathiane ring
Miyauchi, Hiroshi,Tanio, Tomoharu,Ohashi, Naohito
, p. 2377 - 2380 (1996)
A series of azole derivatives containing an oxathiane ring, which were designed to simulate the D ring of lanosterol, were synthesized and evaluated for their antifungal activity. 3,3-Dimethyl derivatives showed potent activity against murine systemic candidosis and aspergillosis, whereas (2R*,3R*)-3-monomethyl derivatives showed only weak activity in both in vitro and in vivo.
