Bioorganic and Medicinal Chemistry Letters p. 2377 - 2380 (1996)
Update date:2022-08-05
Topics:
Miyauchi, Hiroshi
Tanio, Tomoharu
Ohashi, Naohito
A series of azole derivatives containing an oxathiane ring, which were designed to simulate the D ring of lanosterol, were synthesized and evaluated for their antifungal activity. 3,3-Dimethyl derivatives showed potent activity against murine systemic candidosis and aspergillosis, whereas (2R*,3R*)-3-monomethyl derivatives showed only weak activity in both in vitro and in vivo.
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(1995)Doi:10.1016/j.bmcl.2010.04.142
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