Synthesis and antifungal activity of new azole derivatives containing an oxathiane ring

DOI: 10.1016/0960-894X(96)00435-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2377 - 2380 (1996)

Update date:2022-08-05

Topics:

Authors:

Miyauchi, Hiroshi

Tanio, Tomoharu

Ohashi, Naohito

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Article abstract of DOI:10.1016/0960-894X(96)00435-0

A series of azole derivatives containing an oxathiane ring, which were designed to simulate the D ring of lanosterol, were synthesized and evaluated for their antifungal activity. 3,3-Dimethyl derivatives showed potent activity against murine systemic candidosis and aspergillosis, whereas (2R*,3R*)-3-monomethyl derivatives showed only weak activity in both in vitro and in vivo.

Full text of DOI:10.1016/0960-894X(96)00435-0

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Product name:1H-1,2,4-Triazole, 1-[[2-(2,4-difluorophenyl)-3,3-dimethyl-1,4-oxathian-2-yl]methyl]-

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