170586-57-9

Upstream product

• 262846-35-5 4-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-hydroxy-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 262846-28-6 4-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-methylsulfanylthiocarboxyoxy-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 87736-74-1 4-(tert-butyldimethylsiloxymethyl)bromobenzene 
• 262846-29-7 4-(tert-butyl-dimethyl-silanyloxy)-2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-benzyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 170586-58-0 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methanesulfonyloxymethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 170586-59-1 2-(4-azidomethyl-benzyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 262846-11-7 (2R,4S)-2-[4-(Allyloxycarbonylamino-methyl)-benzyl]-4-mercapto-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-30-0 (2R,4S)-4-Acetylsulfanyl-2-[4-(allyloxycarbonylamino-methyl)-benzyl]-pyrrolidine-1-carboxylic acid allyl ester 
• 262845-97-6 2-[4-(allyloxycarbonylamino-methyl)-benzyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio- 1β-methylcarbapenems. Part 1:J-111,347 and related compounds

1β-Methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio- side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum antibiotic showing activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa.

Carbapenem derivatives

A compound of the formula: STR1 wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a negative charge, R3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl group or a gr