262846-29-7

Upstream product

• 262846-35-5 4-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-hydroxy-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 87736-74-1 4-(tert-butyldimethylsiloxymethyl)bromobenzene 
• 262846-28-6 4-(tert-butyl-dimethyl-silanyloxy)-2-{[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-methylsulfanylthiocarboxyoxy-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 262845-97-6 2-[4-(allyloxycarbonylamino-methyl)-benzyl]-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 170586-58-0 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-methanesulfonyloxymethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 170586-59-1 2-(4-azidomethyl-benzyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 170586-57-9 (2R,4R)-N-t-butoxycarbonyl-4-t-butyldimethylsiloxy-2-[(4-hydroxymethyl)benzyl]pyrrolidine 

Relevant academic research and scientific papers

Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio- 1β-methylcarbapenems. Part 1:J-111,347 and related compounds

1β-Methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio- side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum antibiotic showing activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa.