17064-19-6Relevant academic research and scientific papers
Synthesis method of oxazole heterocyclic compound
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, (2020/04/17)
The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to a synthesis method of an oxazole heterocyclic compound. Aryl aldehyde and a triazole derivative are used as raw materials and are heated to react in the presence of trichloromethane and rhodium acetate catalysts to obtain the oxazole heterocyclic compound. By using the method provided by the invention, under the condition of heating and stirring, the oxazole heterocyclic derivative can be obtained at a relatively high yield after reaction for 3-12 hours. According to the method disclosed by the invention, the oxazole heterocyclic derivative is simply, conveniently and efficiently synthesized by using simple and easily available raw materials through a one-step method, and a simple and efficient new synthesis method with wide substrate universality is provided for synthesizing the oxazole heterocyclic derivative.
Synthesis of 2,5-diaryloxazoles through rhodium-catalyzed annulation of triazoles and aldehydes
Li, Jian,Liu, Li,Lu, Xue-Chen,Wang, Zheng-Bing,Xu, De-Feng,Xu, Yue,Zhu, Shang-Rong
, p. 24795 - 24799 (2020/07/14)
An efficient synthesis of a variety of 2,5-diaryloxazole derivatives via a rhodium-catalyzed annulation of triazoles and aldehydes is achieved. Various oxazole derivatives could be obtained in good to excellent yields. A concise synthesis of antimycobaterial natural products balsoxin and texamine has been achieved using this method. This journal is
A cuprous catalytic phenmethyl nitrine with styrene synthesis of 2, 5 - disubstituted-oxazole
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Paragraph 0050; 0051; 0052; 0053; 0054; 0055, (2017/08/25)
The invention discloses a preparation method for synthesizing 2,5-disubstituted oxazoles from benzyl azide and styrene under the catalysis of sub copper. The method comprises the following steps of (1) preparing a substituent azide; (2) reacting azide with styrene to prepare a product. According to the method, the raw materials are simple, reaction conditions are moderate, and the method has high application value, and is suitable for industrial production.
A facile synthesis of 2,5-disubstituted oxazoles via a copper-catalyzed cascade reaction of alkenes with azides
Li, Jiu-Ling,Wang, Ying-Chun,Li, Wei-Ze,Wang, Heng-Shan,Mo, Dong-Liang,Pan, Ying-Ming
, p. 17772 - 17774 (2015/12/18)
A novel and efficient approach to the synthesis of 2,5-disubstituted oxazoles is developed via a 1,3-dipolar cycloaddition/ring cleavage/1,2-H migration/denitrogenation/copper-catalyzed aerobic oxidative dehydrogenative cyclization cascade. The desired products can be obtained from readily available aromatic terminal alkenes and azides employing air as the oxidant under mild conditions, and it offers an attractive alternative method for the synthesis of oxazole derivatives.
