170650-87-0Relevant academic research and scientific papers
Hydrazinecarboxylic acids
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, (2008/06/13)
Disclosed are certain 3-phenylpyridazines, compositions thereof which are herbicidal and methods of using such compositions for controlling undesired plants. Intermediates useful in preparing the 3-phenylpyridazines are disclosed.
Synthesis and reactions of haloazodienes. A new and general synthesis of substituted pyridazines
South, Michael S.,Jakuboski, Terri L.,Westmeyer, Mark D.,Daniel
, p. 8921 - 8934 (2007/10/03)
The reaction of dihalohydrazones with Hunig's base gives 1-carbethoxy-3-phenyl-4-haloazodienes in-situ, which were found to combine with a variety of electron rich olefins to yield halo-substituted tetrahydropynidazines. These haloazodiene cyclizations are best characterized as inverse electron demand, 4 + 2 hetero Diels-Alder reactions that maintain a high degree of regio- and stereochemical control. The chloro-substituted tetrahydropyridazines that are formed give high yields of substituted pyridazines upon treatment with base. The sequence of a chloroazodiene cyclization to a tetrahydropyridazine followed by an aromatization constitutes a new and general synthesis of substituted pyridazines. In contrast to the haloazodiene cyclizations, the novel cyclization reactions of the in-situ generated 1-carbethoxy-3-phenyl-4,4-dichloroazodiene were found to give N-aminopyrroles and pyridazines when combined with acyclic enamines. However, reactions with cyclic enamines gave the N-aminopyrroles, pyridazines, a dihydropyridazine as products as well as the noncyclized enamine intermediates. The noncyclized enamines could be converted to the N-aminopyrroles simply upon heating to higher temperatures, indicating a stepwise mechanism. The examples described here are the first reported cyclization reactions for dichloroazodienes.
Synthesis and reactions of chloroazodienes. A new and general synthesis of pyridazines
South, Michael S.,Jakuboski, Terri L.
, p. 5703 - 5706 (2007/10/02)
The reaction of dichlorohydrazones with Hunig's base gives 4-chloroazodienes, which were found to combine with a variety of electron rich olefins to yield chloro-substituted tetrahydropyridazines. These chloroazodiene cyclizations are best characterized a
