170654-62-3Relevant academic research and scientific papers
A Palladium-Mediated Tandem Carbon-Carbon Bond Forming Method Featuring Nucleophilic Substitution of Intermediate ?-Allylpalladium Complexes Produced via the Heck Reaction
Nylund, Christine S.,Smith, Daniel T.,Klopp, John M.,Weinreb, Steven M.
, p. 9301 - 9318 (1995)
Carbon nucleophiles are alkylated with ?-allylpalladium complexes formed by the palladium-catalyzed Heck reaction of a vinyl bromide and an olefin.This methodology achieves the consecutive formation of two carbon-carbon bonds in one simple operation and can be applied both inter- and intramolecularly.The rapid construction of functionalized carbobicyclic compounds is effected by the intramolecular version of this condensation.
