
Tetrahedron p. 9301 - 9318 (1995)
Update date:2022-08-03
Topics: Palladium Heck reaction Nucleophilic substitution Intermediate Tandem Carbon-Carbon Bond
Nylund, Christine S.
Smith, Daniel T.
Klopp, John M.
Weinreb, Steven M.
Carbon nucleophiles are alkylated with ?-allylpalladium complexes formed by the palladium-catalyzed Heck reaction of a vinyl bromide and an olefin.This methodology achieves the consecutive formation of two carbon-carbon bonds in one simple operation and can be applied both inter- and intramolecularly.The rapid construction of functionalized carbobicyclic compounds is effected by the intramolecular version of this condensation.
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