A Palladium-Mediated Tandem Carbon-Carbon Bond Forming Method Featuring Nucleophilic Substitution of Intermediate ?-Allylpalladium Complexes Produced via the Heck Reaction

Article abstract of DOI:10.1016/0040-4020(95)00518-D

Carbon nucleophiles are alkylated with ?-allylpalladium complexes formed by the palladium-catalyzed Heck reaction of a vinyl bromide and an olefin.This methodology achieves the consecutive formation of two carbon-carbon bonds in one simple operation and can be applied both inter- and intramolecularly.The rapid construction of functionalized carbobicyclic compounds is effected by the intramolecular version of this condensation.