170698-40-5Relevant academic research and scientific papers
Intramolecular palladium-catalyzed oxidative coupling on thiophene and furan rings: Determinant role of the electronic availability of the heterocycle
Beccalli, Egle M.,Borsini, Elena,Broggini, Gianluigi,Rigamonti, Micol,Sottocornola, Silvia
, p. 1053 - 1057 (2008)
The cyclization of N-allyl-N-carbetoxy-substituted aminothiophenes and furans was performed by intramolecular Pd(II)- catalyzed oxidative coupling. The process involves a nucleophilic attack of a heteroaromatic carbon to the internal carbon of the π-olefin complex through a 5-exo-trig ring-formation. Better conditions required PdCl2(MeCN)2 as catalyst, CuCl2 as co-catalyst and an environmentally friendly reoxidant such as O2 to promote the catalytic cycle. Georg Thieme Verlag Stuttgart.
