170703-36-3

Upstream product

• 32841-08-0 <4-13C>benzonitrile 
• 1111-72-4 carbon dioxide 
• 112630-77-0 bromobenzene-1,2,3,4,5,6-¹³C₆ 
• 85167-01-7 4-amino<1-13C>phenol 1-phenyl-5-tetrazolylether 
• 3881-08-1 [1-¹³C]₄-aminophenol 
• 55147-71-2 <4-13C>aniline 
• 3881-07-0 <1-13C>-p-nitro-phenol 
• 153489-14-6 [¹³C₆]-benzaldehyde 
• 125770-94-7 [13C₆]acetophenone 
• 266308-67-2 benzoyl-1,2,3,4,5,6-¹³C₆ chloride 

Relevant academic research and scientific papers

Economical synthesis of 13C-labeled opiates, cocaine derivatives and selected urinary metabolites by derivatization of the natural products

The illegal use of opiates and cocaine is a challenge world-wide, but some derivatives are also valuable pharmaceuticals. Reference samples of the active ingredients and their metabolites are needed both for controlling administration in the clinic and to detect drugs of abuse. Especially, 13C- labeled compounds are useful for identification and quantification purposes by mass spectroscopic techniques, potentially increasing accuracy by minimizing ion alteration/suppression effects. Thus, the synthesis of [acetyl-13C4]heroin, [acetyl-13C4-methyl-13C]heroin, [acetyl-13C2-methyl-13C]6-acetylmorphine, [N-methyl-13C-O-metyl- 13C]codeine and phenyl-13C6-labeled derivatives of cocaine, benzoylecgonine, norcocaine and cocaethylene was undertaken to provide such reference materials. The synthetic work has focused on identifying 13C atom-efficient routes towards these derivatives. Therefore, the 13C-labeled opiates and cocaine derivatives were made from the corresponding natural products.

An efficient synthesis of 13C12-benzoyl peroxide

13C12-Benzoyl peroxide was prepared in overall yield of 78% from 13C6-benzene via acetophenone, benzoic acid and benzoyl chloride intermediates.

Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part III. Syntheses of [2H5]-, [13C8], and [13C7,15N]atorvastatin and their application in metabolic and pharmacokinetic studies

Three stable-isotope-labeled forms of atorvastatin, [2H5], [13C8], and [13C7,15N], were synthesized. They were utilized primarily for metabolic mapping and pharmacokinetic studies of bioequivalence. Analytical assays were performed by using LC/MS/MS methodologies.

Synthesis of selectively 13C-labelled benzoic acid for nuclear magnetic resonance spectroscopic measurement of glycine conjugation activity

The synthesis of [4-13C]benzoic acid (BA) labelled in a single protonated carbon, for use as a probe to measure glycine conjugation activity by nuclear magnetic resonance (NMR) spectroscopy, has been reported. The labelled compound was prepared