170727-59-0

Usage

Uses

Used in Pharmaceutical Industry:
Loratadine Hydrochloride is used as an active pharmaceutical ingredient for the treatment of allergic symptoms such as runny nose, sneezing, and itching. It works by inhibiting the action of histamine, a substance in the body that causes these symptoms.
Used in Research and Development:
Loratadine Hydrochloride is used as an isomer of Loratadine in the preparation of tricyclic amides and ureas. These compounds are useful for the inhibition of G-protein function, which plays a significant role in cellular signaling pathways. This makes Loratadine Hydrochloride a valuable compound for research and development in the pharmaceutical industry.
Used in Treatment of Proliferative Diseases:
Loratadine Hydrochloride is used as a component in the development of treatments for proliferative diseases. Its ability to inhibit G-protein function makes it a potential candidate for therapeutic applications in conditions characterized by abnormal cell growth.

Upstream product

• 79794-75-5 loratadine 

Relevant academic research and scientific papers

Ecotoxic effects of loratadine and its metabolic and light-induced derivatives

Loratadine and desloratadine are second-generation antihistaminic drugs. Because of human administration, they are continuously released via excreta into wastewater treatment plants and occur in surface waters as residues and transformation products (TPs). Loratadine and desloratadine residues have been found at very low concentrations (ng/L) in the aquatic environment but their toxic effects are still not well known. Both drugs are light-sensitive even under environmentally simulated conditions and some of the photoproducts have been isolated and characterized. The aim of the present study was to investigate the acute and chronic ecotoxicity of loratadine, desloratadine and their light-induced transformation products in organisms of the aquatic trophic chain. Bioassays were performed in the alga Pseudokirchneriella subcapitata, the rotifer Brachionus calyciflorus and in two crustaceans, Thamnocephalus platyurus and Ceriodaphnia dubia. Loratadine exerted its acute and chronic toxicity especially on Ceriodaphnia dubia (LC50: 600 μg/L, EC50: 28.14 μg/L) while desloratadine showed similar acute toxicity among the organisms tested and it was the most chronically effective compound in Ceriodaphnia dubia and Pseudokirchneriella subcapitata. Generally, transformation products were less active in both acute and chronic assays.