170729-76-7 Usage
Uses
Used in Pharmaceutical Industry:
Defluoro Aprepitant is used as a NK-1 receptor antagonist for treating severe anxiety disorders. It is employed to alleviate the symptoms of anxiety by blocking the neurokinin-1 receptor, which plays a role in the transmission of anxiety signals in the brain.
Additionally, Defluoro Aprepitant is used as an antidepressant. It helps to improve mood and reduce depressive symptoms by modulating the neurokinin-1 receptor, which is involved in the regulation of mood and emotional responses.
Check Digit Verification of cas no
The CAS Registry Mumber 170729-76-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,7,2 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 170729-76:
(8*1)+(7*7)+(6*0)+(5*7)+(4*2)+(3*9)+(2*7)+(1*6)=147
147 % 10 = 7
So 170729-76-7 is a valid CAS Registry Number.
170729-76-7Relevant academic research and scientific papers
Structural optimization affording 2-(R)-(1-(R)-3,5- bis(trifluoromethyl)phenylethoxy)-3'-(S)-(4-fluoro)phenyl-4-(3-oxo-1,2,4- triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist
Hale, Jeffrey J.,Mills, Sander G.,MacCoss, Malcolm,Finke, Paul E.,Cascieri, Margaret A.,Sadowski, Sharon,Ber, Elzbieta,Chicchi, Gary G.,Kurtz, Marc,Metzger, Joseph,Eiermann, George,Tsou, Nancy N.,Tattersall, F. David,Rupniak, Nadia M. J.,Williams, Angela R.,Rycroft, Wayne,Hargreaves, Richard,MacIntyre, D. Euan
, p. 4607 - 4614 (2007/10/03)
Structural modifications requiring novel synthetic chemistry were made to the morpholine acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2-(R)-(1-(R)-3,5- bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phe
