170751-79-8Relevant academic research and scientific papers
Estereoselectividad de la Adicion de Reactivos de Aluminio y de Magnesio a ((S)R)-2-p-Tolilsulfinilciclohexanonas
Bueno, Ana B.,Carreno, M. Carmen,Ruano, Jose L. Garcia
, p. 442 - 451 (2007/10/02)
The results obtained in the reactions of ((S)R)-2-p-tolylsulfinyl cyclohexanones with several aluminum and magnesium reagents are reported.High diastereoselectivities are observed in the presence of ZnBr2 regardeless of the metal and the nature of the organic residue added (alkyl, aryl, vinyl or ethynyl).An efficient 1,3-asymmetric induction process controlled by the sulfoxide gives rise to tertiary alkylcarbinols with a defined configuration of the new stereogenic center.Key words: ketosulfoxides, nucleophilic addition, optically pure tertiary carbinols, aluminum and Grignard reagents.
