170790-19-9

Upstream product

• 106-38-7 para-bromotoluene 
• 3939-09-1 2,4-difluorobenzonitrile 
• 170789-32-9 (2,4-Difluoro-phenyl)-p-tolyl-methanone 
• 170790-14-4 (E)-3-(2,4-Difluoro-phenyl)-3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Diphenylpropionic acids as new AT1 selective angiotensin II antagonists

The synthesis and pharmacological evaluation of a new series of potent AT1 selective diphenylpropionic acid nonpeptide angiotensin II receptor antagonists are reported. The new compounds were evaluated for in vitro AT1 (rat liver) an

IMIDAZOPYRIDINE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS

The present invention relates to new imidazopyridine derivatives of formula I STR1 wherein: one of A, B, C and D is N and the other are CR, wherein each R independently represents hydrogen, C 1-4 alkyl, COOH or halogen; R 1 represents C 1-4 alkyl or C 3-7 cycloalkyl; Ar 1 represents phenyl or pyridyl which can be optionally substituted; V represents C 1-4 alkyl, C 3-7 cycloalkyl, aryl, aryl-(C 1-4)alkyl or a 5-or 6-membered aromatic heterocycle; the group X-Y represents C=C or CH--CR 3 ; R 3 represents hydrogen, C 1-4 alkyl or aryl-(C 1-4)alkyl; Z represents among others--CO 2 R 4,--tetrazol-5-yl,--CONHSO 2 R 4,--CONR 4 R 5,--CH 2 NHSO 2 R 4 ; R 4 and R 5 independently represent hydrogen, C 1-4 alkyl, aryl, aryl-(C 1-4) alkyl or perfluoro-(C 1-4) alkyl; W represents hydrogen, cyano, C 1-4 alkyl, C 1-4 haloalkyl, C 3-7 cycloalkyl, aryl, aryl-(C 1-4)alkyl, C 1-4 alkylsulfonyl, C 1-4 alkylsulfinyl, C 1-4 alkylthio, C 1-4 alkoxy, C 1-4 alkylcarbonyl, halogen, hydroxymethyl or C 1-4 alkoxymethyl, or W can have any of the meanings disclosed for Z. These compounds are angiotensin II antagonists.