170799-18-5

Upstream product

• 615-62-3 3-chloro-4-methylphenol 
• 933-88-0 ortho-toluoyl chloride 
• 940109-72-8 2-Methyl-benzoic acid 3-chloro-4-methyl-phenyl ester 

Downstream Products

• 137711-65-0 7-Chloro-6-methyl-2-oxo-4-o-tolyl-2H-chromene-3-carboxylic acid ethyl ester 
• 137711-80-9 7-Chloro-6-methyl-2-oxo-4-o-tolyl-2H-chromene-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.