17080-27-2

Upstream product

• 500-98-1 phenylacetylglycine 
• 100-02-7 4-nitro-phenol 
• 94359-70-3 benzyl N-phenylacetylglycinate 
• 157224-44-7 benzyl N-Boc-N-phenylacetylglycinate 
• 157224-37-8 N-Boc-N-phenylacetylglycine 
• 157224-41-4 (tert-Butoxycarbonyl-phenylacetyl-amino)-acetic acid 4-nitro-phenyl ester 

Downstream Products

• 17080-38-5 5,5-dimethyl-2-oxo-3-(N-phenylacetyl-glycyl)-thiazolidine-4-carboxylic acid benzyl ester 
• 130052-08-3 Phenylacetylamino-acetic acid 2-dimethylamino-ethyl ester 
• 47330-74-5 5,5-dimethyl-2-oxo-3-(N-phenylacetyl-glycyl)-thiazolidine-4-carboxylic acid 

Relevant academic research and scientific papers

An efficient synthesis of aryl phenaceturates using acid catalyzed dicyclohexylcarbodiimide esterification and transient N-tert-butoxycarbonylation

Application of the Holmberg procedure (DCC/pyridine/p-TSA(cat)) improves the yield of the direct condensation of phenols with phenylacetylglycine (1). Moreover, N-tert-butoxycarbonylation of 1 impedes an intramolecular reaction leading to an oxazolone, an