170856-57-2Relevant articles and documents
Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds
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, (2008/06/13)
Anti-AIDS compounds of formula (I) STR1 wherein R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification and R8 is alkyl of substituted alkyl.
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs
Genin,Poel,Yagi,Biles,Althaus,Keiser,Kopta,Friis,Reusser,Adams,Olmsted,Voorman,Thomas,Romero
, p. 5267 - 5275 (2007/10/03)
The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substituent on the pyridine ring. This