89694-54-2Relevant academic research and scientific papers
Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
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Page/Page column 97; 98, (2010/08/18)
Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION
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Page/Page column 57, (2008/06/13)
There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS
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Page/Page column 49, (2008/06/13)
There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
Positive allosteric modulators of the nicotinic acetylcholine receptor
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Page 40, (2010/02/05)
The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.
Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds
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, (2008/06/13)
Anti-AIDS compounds of formula (I) STR1 wherein R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification and R8 is alkyl of substituted alkyl.
Heterocyclic compounds for the treatment of CNS and cardiovascular disorders
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, (2008/06/13)
Novel aromatic bicyclic amines of formula (I) STR1 are useful in treating central nervous system disorders and cardiac arrhythmias and cardiac fibrillation.
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: Structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs
Genin,Poel,Yagi,Biles,Althaus,Keiser,Kopta,Friis,Reusser,Adams,Olmsted,Voorman,Thomas,Romero
, p. 5267 - 5275 (2007/10/03)
The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via oxidative N-dealkylation of the 3-ethyl- or 3-isopropylamino substituent on the pyridine ring. This
