170860-51-2Relevant academic research and scientific papers
Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators
Zhang, Xuqing,Allan, George F.,Sbriscia, Tifanie,Linton, Olivia,Lundeen, Scott G.,Sui, Zhihua
, p. 5763 - 5766 (2008/12/22)
A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed that the function of the ligand could be altered by minor structural modification.
Optionally substituted phenylimidazolidines, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them
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, (2008/06/13)
A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula STR1 wherein Y is --O--, Z 2 is --CF 3, Z 1 is --CN or --NO 2, X is --O-- or --S--, R 3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or --CN and R 4 and R 5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, --OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or --OH, and wherein at least one of R 4 and R 5 is substituted having antiandrogenic activity.
