170862-13-2Relevant academic research and scientific papers
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV- 2 replication by antagonism of the chemokine receptor CXCR4
Bridger, Gary J.,Skerlj, Renato T.,Padmanabhan, Sreenivasan,Martellucci, Stephen A.,Henson, Geoffrey W.,Struyf, Sofie,Witvrouw, Myriam,Schols, Dominique,De Clercq, Erik
, p. 3971 - 3981 (2007/10/03)
Bis-tetraazamacrocycles such as the bicyclam AMD3100 are a class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. With the aim of optimi
