46133-38-4

Usage

Uses

Used in Pharmaceutical Synthesis:
(6-cyanomethylpyridin-2-yl)acetonitrile is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the creation of a wide range of pharmaceutical compounds, contributing to the development of new medications.
Used in Agrochemical Production:
In the agrochemical industry, (6-cyanomethylpyridin-2-yl)acetonitrile serves as a crucial intermediate in the production of different agrochemicals. Its incorporation aids in the development of novel compounds with potential applications in agriculture, such as pesticides and herbicides.
Used in Organic Chemistry Research:
(6-cyanomethylpyridin-2-yl)acetonitrile is utilized as a valuable building block in organic chemistry research. Its ability to form heterocyclic compounds makes it an essential component in the synthesis of complex organic molecules, furthering scientific understanding and innovation in the field.
Used in Medicinal Chemistry:
(6-cyanomethylpyridin-2-yl)acetonitrile is also investigated for its potential pharmacological properties in the field of medicinal chemistry. Its unique structure and reactivity make it a promising candidate for the development of new therapeutic agents and the enhancement of existing medications.

Upstream product

• 7703-74-4 2,6-bis-(bromomethyl)pyridine 
• 13435-20-6 tetraethylammoniumcyanide 
• 3099-28-3 2,6-bis(chloromethyl)pyridine 
• 209215-55-4 6-bromomethylpyridine-2-carboxylic acid ethylester 
• 5453-67-8 2,6-bis(methoxycarbonyl)pyridine 
• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 73004-40-7 2,6-bis-(bromomethyl)pyridine hydrobromide 

Downstream Products

• 209215-55-4 6-bromomethylpyridine-2-carboxylic acid ethylester 
• 170862-14-3 C₆₆H₈₂N₈O₈S₄ 
• 170862-10-9 C₆₂H₇₄N₈O₈S₄ 
• 170862-13-2 4,12-bis(p-toluenesulfonyl)-4,8,12,19-tetraazabicyclo[15.3.1]nonadeca-1⁽¹⁹⁾,15,17-triene 
• 170862-09-6 4,10-bis(p-toluenesulfonyl)-4,7,10,17-tetraazabicyclo[13.3.1]heptadeca-1⁽¹⁷⁾,13,15-triene 
• 170862-07-4 2,6-bis(N,N'-p-toluenesulfonyl-2-aminoethyl)pyridine 

Relevant academic research and scientific papers

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.

Synthesis of bis(amidoxime)s and evaluation of their properties as uranyl-complexing agents

Uranium pollution involves high toxicity and radioactivity and, therefore, constitutes a grave threat to human health and the environment. Chelation is an effective method for sequestering uranium. It is well known that chelators based on oxime groups are able to complex uranyl cations efficiently. To this end, various bis(amidoxime)s were synthesized by reaction of hydroxylamine with the corresponding dinitriles. In these compounds the amidoximes are separated by chains of various lengths, some including a heterocycle (pyridine or 1,3,5-triazine). The abilities of these bis(amidoxime)s to complex uranyl cation in water were evaluated by determining their affinity constants and thermodynamic parameters by means of Isothermal Titration Calorimetry (ITC). DFT calculations were also performed, to determine the optimum structures of the complexes formed between uranyl cations and the oximate groups. A tetrakis(amidoxime), also synthesized in this work, shows good affinity for uranium, and a single molecule is able chelate several uranyl cations. These results are of importance for the remediation of uranium-polluted wastewaters, and open up several perspectives for the design and synthesis of new amidoxime compounds.

VANADIUM INSULIN-MIMETICS, METHODS OF PREPARATION, AND METHODS FOR TREATMENT OF DIABETES

Disclosed are vanadyl complexes of Formula 1, Formula 2, and Formula 3, wherein Ri, R2, and R are defined as in the description. The pharmaceutical compositions containing these complexes and uses of the complexes for treatment of Diabetes Mellitus, such as Diabetes Mellitus Type 2, are also disclosed.

Corresponding amine nitrile and method of manufacturing thereof (by machine translation)

The present invention relates to a nitrile manufacturing method, which has characteristics of significantly-reduced ammonia source consumption, low environmental pressure, low energy consumption, low production cost, high nitrile purity, high nitrile yield and the like compared with the method in the prior art, wherein nitrile having a complicated structure can be obtained through the method. The present invention further relates to a method for producing a corresponding amine from the nitrile.

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.

Exploiting protein fluctuations at the active-site Gorge of human cholinesterases: Further optimization of the design strategy to develop extremely potent inhibitors

Protein conformational fluctuations are critical for biological functions, although the relationship between protein motion and function has yet to be fully explored. By a thorough bioinformatics analysis of cholinesterases (ChEs), we identified specific hot spots, responsible for protein fluctuations and functions, and those active-site residues that play a role in modulating the cooperative network among the key substructures. This drew the optimization of our design strategy to discover potent and reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase (hAChE and hBuChE) that selectively interact with specific protein substructures. Accordingly, two tricyclic moieties differently spaced by functionalized linkers were investigated as molecular yardsticks to probe the finest interactions with specific hot spots in the hChE gorge. A number of SAR trends were identified, and the multisite inhibitors 3a and 3d were found to be the most potent inhibitors of hBuChE and hAChE known to date.

D-proline derivatives

New compounds have the formula: wherein R, R1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV- 2 replication by antagonism of the chemokine receptor CXCR4

Bis-tetraazamacrocycles such as the bicyclam AMD3100 are a class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. With the aim of optimi

Cyclic polyamines

Linked polyamine cyclic compounds of general formula V--R--A--R'--W where V and W are independently cyclic polyamine moieties having from 9 to 32 ring members and 3 to 8 amine nitrogens and having either one or more aromatic rings fused thereto or a heter

Studies on the mechanism of chelate degradation in iron-based, liquid redox H2S removal processes

Available data on the oxidation of nitrilotriacetic acid (NTA), ethylenedinitrilotetraacetic acid (EDTA), N-hydroxyethylethylenediaminetriacetic acid (HEDTA), and other aminopolycarboxylate chelating agents are reviewed and the intermediates and products of the oxidative degradation of each chelating agent are described and compared.The oxidation of these chelating agents occurs during the reoxidation of the ferrous chelatre to the ferric chelate, during which a Fenton type side reaction occurs in which hydrogen peroxides is formed and which in turn generates the hydroxyl radical by reaction with ferrous ion.The site of oxidative attack by the hydroxyl radical on these ligands seems to be the -CH2- groups α to the carboxylate groups, as well as the -CH2- groups in the ethylene bridges between the nitrogens.The evidence for the implication of the hydroxyl radical as the active oxidant is discussed, and the use of phenyl-tert-butylnitrone (PBN) as the trapping agent for the hydroxyl radical is described.The use of chelating agents as Fe3+/Fe2+ redox catalysts for the oxidation of H2S to sulfur that are less reactive toward the hydroxyl radical is recommended. Key words: chelate degradation, H2S oxidation, nitrilotriacetic acid (NTA), ethylenedinitrilotetraacetic acid (EDTA), N-hydroxyethylethylenediaminetriacetic acid (HEDTA).