46133-38-4

Basic information

• Product Name: (6-cyanomethylpyridin-2-yl)acetonitrile
• Synonyms: (6-cyanomethylpyridin-2-yl)acetonitrile
• CAS NO: 46133-38-4
• Molecular Weight: 157.175
• Mol File: 46133-38-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (6-cyanomethylpyridin-2-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (6-cyanomethylpyridin-2-yl)acetonitrile(46133-38-4)
• EPA Substance Registry System: (6-cyanomethylpyridin-2-yl)acetonitrile(46133-38-4)

Safety Data

• Hazardous Substances Data: 46133-38-4(Hazardous Substances Data)

Usage

General Description

(6-cyanomethylpyridin-2-yl)acetonitrile is a chemical compound with the molecular formula C9H7N3. It is a pyridine derivative with a cyanomethyl group attached to the 6th position of the pyridine ring. (6-cyanomethylpyridin-2-yl)acetonitrile is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its ability to act as a building block in the construction of various heterocyclic compounds. Additionally, it has been investigated for its potential pharmacological properties, particularly in the field of medicinal chemistry. Overall, this chemical has versatile applications and is valuable in various research and industrial processes.

Upstream product

• 151-50-8 potassium cyanide 
• 3099-28-3 2,6-bis(chloromethyl)pyridine 
• 209215-55-4 6-bromomethylpyridine-2-carboxylic acid ethylester 
• 5453-67-8 2,6-bis(methoxycarbonyl)pyridine 
• 7703-74-4 2,6-bis-(bromomethyl)pyridine 
• 13435-20-6 tetraethylammoniumcyanide 
• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 
• 143-33-9 sodium cyanide 
• 73004-40-7 2,6-bis-(bromomethyl)pyridine hydrobromide 

Downstream Products

• 209215-55-4 6-bromomethylpyridine-2-carboxylic acid ethylester 
• 170862-14-3 C₆₆H₈₂N₈O₈S₄ 
• 170862-10-9 C₆₂H₇₄N₈O₈S₄ 
• 170862-13-2 4,12-bis(p-toluenesulfonyl)-4,8,12,19-tetraazabicyclo[15.3.1]nonadeca-1⁽¹⁹⁾,15,17-triene 
• 170862-09-6 4,10-bis(p-toluenesulfonyl)-4,7,10,17-tetraazabicyclo[13.3.1]heptadeca-1⁽¹⁷⁾,13,15-triene 
• 170862-07-4 2,6-bis(N,N'-p-toluenesulfonyl-2-aminoethyl)pyridine 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.

Corresponding amine nitrile and method of manufacturing thereof (by machine translation)

The present invention relates to a nitrile manufacturing method, which has characteristics of significantly-reduced ammonia source consumption, low environmental pressure, low energy consumption, low production cost, high nitrile purity, high nitrile yield and the like compared with the method in the prior art, wherein nitrile having a complicated structure can be obtained through the method. The present invention further relates to a method for producing a corresponding amine from the nitrile.

Synthesis of bis(amidoxime)s and evaluation of their properties as uranyl-complexing agents

Uranium pollution involves high toxicity and radioactivity and, therefore, constitutes a grave threat to human health and the environment. Chelation is an effective method for sequestering uranium. It is well known that chelators based on oxime groups are able to complex uranyl cations efficiently. To this end, various bis(amidoxime)s were synthesized by reaction of hydroxylamine with the corresponding dinitriles. In these compounds the amidoximes are separated by chains of various lengths, some including a heterocycle (pyridine or 1,3,5-triazine). The abilities of these bis(amidoxime)s to complex uranyl cation in water were evaluated by determining their affinity constants and thermodynamic parameters by means of Isothermal Titration Calorimetry (ITC). DFT calculations were also performed, to determine the optimum structures of the complexes formed between uranyl cations and the oximate groups. A tetrakis(amidoxime), also synthesized in this work, shows good affinity for uranium, and a single molecule is able chelate several uranyl cations. These results are of importance for the remediation of uranium-polluted wastewaters, and open up several perspectives for the design and synthesis of new amidoxime compounds.