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Acutumine is a naturally occurring alkaloid that has been isolated from the plant Acronychia baueri, which is native to Australia. It is a potent and selective inhibitor of the enzyme acetylcholinesterase, which is responsible for the breakdown of the neurotransmitter acetylcholine. This makes acutumine a potential candidate for the treatment of diseases such as Alzheimer's, where a reduction in acetylcholine levels is observed. Acutumine has also been found to exhibit anti-inflammatory and analgesic properties, making it a promising compound for the development of new pharmaceuticals. Furthermore, studies have shown acutumine to have anticancer and antimalarial activities, highlighting its potential as a versatile and valuable chemical compound with a variety of potential applications in medicine and drug development.

17088-50-5

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17088-50-5 Usage

Uses

Used in Pharmaceutical Industry:
Acutumine is used as a potential treatment for Alzheimer's disease due to its ability to inhibit the enzyme acetylcholinesterase, thereby increasing acetylcholine levels in the brain.
Acutumine is used as an anti-inflammatory and analgesic agent for the development of new pharmaceuticals, owing to its observed anti-inflammatory and analgesic properties.
Used in Anticancer Applications:
Acutumine is used as an anticancer agent, as studies have shown its potential to exhibit anticancer activities.
Used in Antimalarial Applications:
Acutumine is used as an antimalarial agent, as it has been found to possess antimalarial activities.

Check Digit Verification of cas no

The CAS Registry Mumber 17088-50-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,8 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 17088-50:
(7*1)+(6*7)+(5*0)+(4*8)+(3*8)+(2*5)+(1*0)=115
115 % 10 = 5
So 17088-50-5 is a valid CAS Registry Number.

17088-50-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Acutumin

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17088-50-5 SDS

17088-50-5Downstream Products

17088-50-5Relevant academic research and scientific papers

Total syntheses of (-)-acutumine and (-)-dechloroacutumine

King, Sandra M.,Calandra, Nicholas A.,Herzon, Seth B.

, p. 3642 - 3645 (2013)

One route fits all: Syntheses of the title complex tetracyclic alkaloids are described. The routes feature the strategic application of 5-trimethylsilylcyclopentadiene, a selective hydrostannylation of a complex enyne, a Hosomi-Sakurai cyclization to form the skeleton of the targets, an allylic formate rearrangement to construct the spirocyclopentenone rings, and a selective hydrogenation to establish the alkyl chloride functional group of (-)-acutumine. Copyright

Total synthesis of (-)-acutumine

Li, Fang,Tartakoff, Samuel S.,Castle, Steven L.

supporting information; experimental part, p. 6674 - 6675 (2009/10/30)

(Chemical Equation Presented) The first total synthesis of the tetracyclic alkaloid (-)-acutumine is described. Key reactions include an asymmetric ketone allylation mediated by Nakamura's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, and t

Enantioselective total synthesis of (-)-acutumine

Li, Fang,Tartakoff, Samuel S.,Castle, Steven L.

experimental part, p. 9082 - 9093 (2010/03/04)

(Chemical Equation Presented) An account of the total synthesis of the tetracyclic alkaloid (-)-acutumine is presented. A first-generation approach to the spirocyclic subunit was unsuccessful as a result of incorrect regioselectivity in a radical cyclizat

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