170886-13-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE is used as a building block for the synthesis of various medications due to its unique structural and chemical properties that can be leveraged to create new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE serves as a key component in the development of pesticides, where its specific attributes can enhance the effectiveness of these products.
Used in Organic Synthesis:
2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE is utilized as a reagent in organic synthesis, particularly for the production of heterocyclic compounds, which are important in a variety of chemical and pharmaceutical applications.
Overall, 2-(TRIFLUOROMETHYL)-4-HYDROXYPYRIDINE is an important chemical intermediate with diverse applications across medicine, agriculture, and organic chemistry, underpinning its significance in these fields.

InChI:InChI=1/C6H4F3NO/c7-6(8,9)5-3-4(11)1-2-10-5/h1-3H,(H,10,11)

Upstream product

• 204516-31-4 2-(trifluoromethyl)-4H-pyran-4-one 
• 131747-41-6 2-(trifluoromethyl)-4-pyridinecarboxylic acid 
• 887583-90-6 4-bromo-2-(trifluoromethyl)pyridine 
• 1297137-03-1 methyl 5-cyclopropyl-7-(trifluoromethyl)pyrazolo [1,5-a]pyridine-2-carboxylate 
• 1297137-02-0 methyl 7-(trifluoromethyl)-5-{[(trifluoromethyl)sulfonyl]oxy}pyrazolo[1,5-a]pyridine-2-carboxylate 
• 1297137-00-8 methyl 5-hydroxy-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylate 
• 1297136-86-7 5-hydroxy-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 1297137-87-1 dimethyl 5-(ethyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2,3-dicarboxylate 
• 1297136-82-3 5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 1297136-80-1 dimethyl 5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2,3-dicarboxylate 
• 1297137-35-9 3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 1297137-78-0 1-(3-methylcyctopentyl)-2-piperazinone hydrochloride 
• 1297137-34-8 methyl 3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylate 

Downstream Products

• 630125-72-3 4-(4-nitrophenoxy)-2-(trifluoromethyl)pyridine 
• 1297137-70-2 4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-(4-hydroxycyclohexyl)-2-piperazinone 
• 1297142-94-9 4-{[3-bromo-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-(4-hydroxycyclohexyl)-2-piperazinone 
• 1297136-82-3 5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 1297137-84-8 1-amino-4-(ethyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate 
• 1297139-80-0 4-{[3-chloro-5-cyclopropyl-7-(triftuoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-(2-fluoro-4-methylphenyl)-2-piperazinone 
• 1297141-01-5 5-cyclopropyl-3-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 1297141-07-1 4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-[2-fluoro-4-(methyloxy)phenyl]-2-piperazinone 
• 1297141-30-0 4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-[2-fluoro-4-hydroxyphenyl]-2-piperazinone 
• 1297141-40-2 4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-(4-cyclopropyl-2-fluorophenyl)-2-piperazinone 
• 1297141-41-3 4-(4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-2-oxo-1-piperazinyl)-3-fluorophenyl trifluoromethanesulfonate 
• 1297141-43-5 [4-(4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-2-oxo-1-piperazinyl)-3-fluorophenyl]boronic acid 
• 1297141-46-8 4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-piperazinon 
• 1297141-67-3 4-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-1-[(1R)-1-({[(1,1-dimethylethyl)(diphenyl)silyl]oxy}methyl)-2-propen-1-yl]-2-piperazinone 

Relevant academic research and scientific papers

Decarboxylative Hydroxylation of Benzoic Acids

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.

Dual aminoquinolate diarylboron and nickel catalysed metallaphotoredox platform for carbon-oxygen bond construction

Herein, aminoquinolate diarylboron complexes are utilized as photocatalysts in dual Ni/photoredox catalyzed carbon-oxygen construction reactions. Via this unified metallaphotoredox platform, diverse (hetero)aryl halides can be conveniently coupled with acids, alcohols and water. This method features operational simplicity, broad substrate scope and good compatibility with functional groups. This journal is

2,3-DIHYDROIMIDAZO[1 ,2-c] PYRIMIDIN-5(1 H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS

Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

2,3-DIHYDROIMIDAZO[1,2-C] PYRIMIDIN-5(1H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS

Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA2, processes for their preparation, compositions containing them and their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer?s disease

PROCESS FOR PREPARING 4-HYDROXYPYRIDINES

A process for preparing 4-hydroxypyridines of formula I, wherein R1, R2, R3 and R4 have the meaning defined in the description.

PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and/or Formula (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).