170893-64-8

Usage

Uses

Used in Pharmaceutical Industry:
(4-Aminophenyl)-4-pyridinyl-methanone is used as a potential therapeutic agent for its pharmacological properties. It is being studied for its potential applications in cancer treatment, anti-inflammatory drugs, and psychiatric medications due to its unique chemical structure and properties.
Used in Cancer Treatment:
(4-Aminophenyl)-4-pyridinyl-methanone is used as a potential anticancer agent, targeting various types of cancer. Its specific application reason is still under investigation, but its chemical structure suggests that it may have the ability to interact with cellular targets and modulate signaling pathways involved in cancer progression.
Used in Anti-Inflammatory Drugs:
(4-Aminophenyl)-4-pyridinyl-methanone is used as a potential anti-inflammatory agent, potentially providing relief from inflammation and associated pain. The exact mechanism of action is still under research, but its chemical structure may allow it to interfere with inflammatory processes.
Used in Psychiatric Medications:
(4-Aminophenyl)-4-pyridinyl-methanone is used as a potential agent for psychiatric disorders, possibly due to its ability to interact with neurotransmitter systems in the brain. Further research is needed to determine its efficacy and safety in this application area.

InChI:InChI=1/C12H10N2O/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-8H,13H2

Upstream product

• 853566-15-1 N-[4-(Pyridine-4-carbonyl)-phenyl]-acetamide 
• 27692-74-6 4-(4-aminobenzyl)pyridine 
• 108-89-4 picoline 
• 62-53-3 aniline 
• 1083-48-3 4-Nitrobenzylpyridin 
• 39055-88-4 (4-nitrophenyl)(pyridin-4-yl)methanone 

Downstream Products

• 100867-67-2 N-(4-isonicotinoyl-phenyl)-N'-methyl-thiourea 
• 1370651-40-3 C₃₅H₃₄Cl₂FN₅O₇ 

Relevant academic research and scientific papers

Metal-free oxidative: Para -acylation of unprotected anilines with N-heteroarylmethanes

A selective oxidative para-acylation of unprotected anilines with methyl groups in N-heteroarylmethanes was achieved. This transformation proceeds under mild metal-free reaction conditions to produce the corresponding valuable diarylmethanones in good to high yields, featuring high site-selectivity, high functional-group-tolerance, gram-scale synthesis and easy product-derivation. Preliminary mechanistic studies revealed that the present oxidative para-acylation would take place via a Friedel-Crafts-type process of in situ imines and the steric hindrance might be the key issue for the high regio-selectivity.

Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen

The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP-MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit.

Urea thiadiazole inhibitors of plasminogen activator inhibior-1

Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).

Studies on the Insecticidal Activities of Some New N-Benzoyl-N'-Arylureas

This paper reports the synthesis and the insecticidal activities of some N-benzoyl-N'-arylureas 4-arylsubstituted with alkylated or halogenated aroyl moieties. The compounds, tested against some representative insect species, displayed very high activity against Aedes aegypti, especially the halosubstituted derivatives. None of the newly synthesized compounds showed genotoxic activity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.