170893-64-8

Basic information

• Product Name: (4-Aminophenyl)-4-pyridinyl-methanone
• Synonyms: (4-Aminophenyl-4-Py
• CAS NO: 170893-64-8
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.23
• Mol File: 170893-64-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154-155 °C
• Boiling Point: 400.9°C at 760 mmHg
• Flash Point: 196.3°C
• Appearance: /
• Density: 1.215g/cm³
• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.634
• PKA: 3.25±0.10(Predicted)
• CAS DataBase Reference: (4-Aminophenyl)-4-pyridinyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Aminophenyl)-4-pyridinyl-methanone(170893-64-8)
• EPA Substance Registry System: (4-Aminophenyl)-4-pyridinyl-methanone(170893-64-8)

Safety Data

• Hazardous Substances Data: 170893-64-8(Hazardous Substances Data)

Usage

General Description

(4-Aminophenyl)-4-pyridinyl-methanone, also known as AP-4-Pyridinyl, is a chemical compound with potential pharmacological properties. It is a ketone derivative with a pyridine ring and an aminophenyl group, making it a potential candidate for drug development. AP-4-Pyridinyl has been studied for its potential applications in various therapeutic areas, including cancer treatment, anti-inflammatory drugs, and psychiatric medications. Its structure and properties make it suitable for further research and potential use in medical applications. However, further studies are needed to fully understand the potential benefits and risks of this compound.

InChI:InChI=1/C12H10N2O/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-8H,13H2

Upstream product

• 27692-74-6 4-(4-aminobenzyl)pyridine 
• 108-89-4 picoline 
• 62-53-3 aniline 
• 853566-15-1 N-[4-(Pyridine-4-carbonyl)-phenyl]-acetamide 
• 1083-48-3 4-Nitrobenzylpyridin 
• 39055-88-4 (4-nitrophenyl)(pyridin-4-yl)methanone 

Downstream Products

• 1370651-40-3 C₃₅H₃₄Cl₂FN₅O₇ 
• 100867-67-2 N-(4-isonicotinoyl-phenyl)-N'-methyl-thiourea 

Relevant articles and documents

Metal-free oxidative: Para -acylation of unprotected anilines with N-heteroarylmethanes

A selective oxidative para-acylation of unprotected anilines with methyl groups in N-heteroarylmethanes was achieved. This transformation proceeds under mild metal-free reaction conditions to produce the corresponding valuable diarylmethanones in good to high yields, featuring high site-selectivity, high functional-group-tolerance, gram-scale synthesis and easy product-derivation. Preliminary mechanistic studies revealed that the present oxidative para-acylation would take place via a Friedel-Crafts-type process of in situ imines and the steric hindrance might be the key issue for the high regio-selectivity.

Urea thiadiazole inhibitors of plasminogen activator inhibior-1

Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).