170895-01-9Relevant academic research and scientific papers
Mechanistic insights into Br?nsted acid-induced nucleophilic substitution of aliphatic imidazole carbamate with halide ions
Saputra, Mirza A.,Forgey, Rashel L.,Henry, Jeffrey L.,Kartika, Rendy
, p. 1392 - 1396 (2015/03/04)
Herein we report interesting reactivity of imidazole carbamate towards nucleophilic substitution with halide ions under Br?nsted acidic conditions. Depending upon reaction conditions, halide ions could readily attack the carboxyl position and trigger decarboxylative alkyl halide formation. Alternatively, halide ions were also found to competitively undergo nucleophilic acyl substitution, which ultimately results in the generation of carbonate dimerization product.
Simple method for the preparation of esters from Grignard reagents and alkyl 1-imidazolecarboxylates
Werner, Thomas,Barrett, Anthony G. M.
, p. 4302 - 4304 (2007/10/03)
The reaction of Grignard reagents with alkyl imidazolecarboxylates, which were prepared from alcohols with carbonyl diimidazole, gave the corresponding esters in good to excellent yields. This method conveniently provides esters from alkyl halides and alcohols by C1-carbon chain extension.
Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects
Wilkinson, Douglas E.,Thomas IV, Bert E.,Limburg, David C.,Holmes, Agnes,Sauer, Hansjorg,Ross, Douglas T.,Soni, Raj,Chen, Yi,Guo, Hong,Howorth, Pamela,Valentine, Heather,Spicer, Dawn,Fuller, Mike,Steiner, Joseph P.,Hamilton, Gregory S.,Wu, Yong-Qian
, p. 4815 - 4825 (2007/10/03)
Nonimmunosuppressant ligands, exemplified by GPI 1046 (1), for the peptidyl-prolyl isomerase FKBP12 have been found to unexpectedly possess powerful neuroprotective and neuroregenerative effects in vitro and in vivo. We have extensively explored the thera
SYNTHESIS OF ENOL CARBONATES FROM A REACTION OF SILYL ENOLATES WITH 1H-IMIDAZOLYLURETHANE
Ohta, Shunsaku,Yamashita, Masayuki,Nagai, Nobuaki,Kawasaki, Ikuo,Maeda, Kazuto,Miyano, Yoshiko
, p. 1683 - 1690 (2007/10/03)
Enol carbonates (6) were prepared by treatment of trimethylsilyl enolates (5) with 1-alkoxycarbonyl-1H-imidazoles (2) in the presence of boron trifluoride etherate and tetrabutylammonium fluoride.
