1708971-72-5 Usage
Uses
Used in Oncology:
FGFR4-IN-1 is used as an anticancer agent for the treatment of liver cancer and colorectal cancer. It targets and inhibits the activity of fibroblast growth factor receptor 4 (FGFR4), which is implicated in the growth and spread of these cancer types. By suppressing FGFR4 signaling, FGFR4-IN-1 may help control tumor progression and improve patient outcomes.
Used in Drug Development:
FGFR4-IN-1 is used as a research tool in the development of targeted therapies for cancer treatment. Its ability to inhibit FGFR4 makes it a valuable compound for studying the role of FGFR4 in cancer progression and for identifying potential therapeutic targets. This can contribute to the advancement of personalized medicine and the discovery of novel cancer treatments.
Used in Preclinical Research:
FGFR4-IN-1 is used as a preclinical model compound to investigate the mechanisms of action and potential side effects of FGFR4 inhibition. This helps researchers understand the safety and efficacy of FGFR4-IN-1 before it proceeds to clinical trials, ensuring that it has the potential to become a viable treatment option for patients.
Used in the Study of FGFR4-Related Diseases:
FGFR4-IN-1 is used in research to explore the role of FGFR4 in various diseases and conditions beyond cancer. By inhibiting FGFR4, researchers can gain insights into the potential therapeutic benefits of targeting this receptor in other disease contexts, such as fibrosis, inflammation, and tissue repair. This can lead to the development of new treatment strategies for a broader range of health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 1708971-72-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,0,8,9,7 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1708971-72:
(9*1)+(8*7)+(7*0)+(6*8)+(5*9)+(4*7)+(3*1)+(2*7)+(1*2)=205
205 % 10 = 5
So 1708971-72-5 is a valid CAS Registry Number.
1708971-72-5Relevant academic research and scientific papers
Sun, Chang'an,Fang, Lei,Zhang, Xiaobing,Gao, Peng,Gou, Shaohua
, p. 1932 - 1941 (2019)
Total twenty-five 7-formyl-naphthyridyl-urea derivatives were designed, synthesized and evaluated for their inhibition of FGFR4 kinase and antitumor activity. The pharmacological data indicated that most of the tested compounds showed high selectivity towards FGFR4 kinase and could significantly inhibit FGFR4 and the tumor cells lines with the high expression of FGFR4. In particular, compounds 6f, 6g, 6h, 6l, 6m and 6s showed a good performance in pharmacokinetic tests. When tested in mice, the representative compound 6f was found to have good pharmacokinetic parameters, low toxicity, and better tumor inhibiting activity in vivo.
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
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Paragraph 1252-1255; 1269-1272, (2015/05/05)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
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Page/Page column 215; 216; 218, (2015/05/06)
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
