1709-14-4

Usage

Uses

Used in Chemical Research and Synthesis:
3,3-dichloroazepan-2-one is used as a chemical intermediate for the synthesis of various organic compounds and pharmaceuticals. Its unique structure and functional groups make it a valuable building block in the development of new molecules with specific properties and applications.
Used in Pharmaceutical Industry:
3,3-dichloroazepan-2-one is used as a key component in the development of pharmaceutical compounds. Its structural features and functional groups can be exploited to design and synthesize new drugs with potential therapeutic applications. 3,3-dichloroazepan-2-one's reactivity and versatility in chemical reactions allow for the creation of diverse drug candidates with improved efficacy and selectivity.
Used in Agrochemical Industry:
3,3-dichloroazepan-2-one is utilized as a starting material or intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique chemical properties and reactivity enable the development of novel agrochemicals with enhanced performance, selectivity, and environmental compatibility.
Used in Material Science:
3,3-dichloroazepan-2-one can be employed in the development of advanced materials with specific properties, such as polymers, coatings, and adhesives. Its chemical structure and functional groups can be tailored to achieve desired characteristics, such as improved mechanical strength, thermal stability, or chemical resistance.

Upstream product

• 105-60-2 caprolactam 
• 100-64-1 cyclohexanone-oxime 
• 7732-18-5 water 
• 56-23-5 tetrachloromethane 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 1468-55-9 3-chloro-hexahydro-azepin-2-one 
• 189261-36-7 3-(4-nitrobenzyloximino)hexahydroazepin-2-one 
• 26536-94-7 1-benzoyl-3-chloro-hexahydro-azepin-2-one 

Relevant academic research and scientific papers

New calcium antagonists: Synthesis, X-ray analysis, and smooth muscle relaxing effect of 3-[O-(benzyl-substituted)-oximino-ethers]-hexahydroazepin-2,3-diones

A series of new Z and E 3-[O-(benzyl-substituted)-oximino-ether]-hexahydroazepin-2,3-diones was prepared from the corresponding hexahydroazepin-2,3-diones and examined as smooth muscle relaxants. E and Z structures were assigned by NMR analysis and confirmed for 16 (E and Z) by an X-ray diffraction using synchrotron radiations. The nitrobenzyl derivative 16 was the most potent in vitro as relaxant of rat trachea precontracted with acetylcholine. The E isomer 16b was more potent than the Z isomer 16a. E isomer 16b is more potent than aminophylline to relax both rat trachea and human bronchus.This derivative acts mainly by inhibiting cellular infux of extracellular calcium since it inhibits potently and dose-dependently the contractions of rat trachea to high concentrations of KCl and to CaCl2 in a depolarizing medium. It appears to act weakly by inducing cGMP and cAMP synthesis. Moreover, its relaxing activity is not related to an inhibition of phosphodiesterases, to opening of potassium channels or to induction of prostaglandin synthesis. Therefore, 16b appears to work mainly as a potent calcium antagonist. (C) 1999 Elsevier Science Ltd.

SYNTHESIS OF NEW α-CHLOROACRYL-AMIDES, THIOAMIDES AND AMIDINES FROM SATURATED AMIDES.

Chlorination of saturated amide chlorides followed by hydrolysis, thiolysis, aminolysis and catalysed dehydrochlorination leads to α-chloro acrylamide derivatives in high yield.The reaction sequence is applied to lactames and can also be extended to the synthesis of α-chloro acrylthioamide and amidine.

Radiosensitization of human pancreatic cancer by piperlongumine analogues

Radiotherapy is commonly used to treat advanced pancreatic cancers and can improve survival by 2 months in combination with gemcitabine. However, prognosis and survival improvement remain unsatisfactory, and effective therapies are urgently needed. Piperlongumine has been demonstrated to have therapeutic potentials against various cancers. In this study, we synthesized a series of piperlongumine derivatives and provided evidence that piperlongumine derivatives could be used as effective radiosensitizers in pancreatic cancer. Two compounds enhanced the radiosensitivity of Panc-1 and SW1990 cells. In a pancreatic bi-flank xenograft tumor model, they significantly inhibited tumor growth. Piperlongumine derivatives could induce reactive oxygen species (ROS) expression and regulate the Keap1-Nrf2 protective pathway with enhancement of radiation-induced DNA damage, G2/M-phase cell cycle arrest, and apoptosis. Collectively, our data offer a proof of concept for the use of piperlongumine derivatives as a novel class of radiosensitizers for the treatment of pancreatic cancer.

PIPERLONGUMINE ANALOGUES AND USES THEREOF

The present disclosure provides compositions and methods for selectively killing senescent cells, wherein the composition comprises piperlongumine derivative thereof. The selective killing of senescent cells may delay aging and/or treat age-related disorders.

Piper longum amide analogue containing seven-membered lactam ring and preparation method and application thereof

The invention relates to the technical field of medicine, in particular to a substitutive piper longum amide analogue. The substitutive piper longum amide analogue comprises cis-trans-isomers thereof and any mixture in the form of cis-trans-isomers or pharmaceutical salt of the analogue. The structure of the substitutive piper longum amide analogue is shown in the formula (I). The invention further provides a preparation method of the substitutive piper longum amide compound and application of the substitutive piper longum amide compound to preparation of antitumor drugs.