170914-43-9Relevant academic research and scientific papers
Pyrone derivatives as protease inhibitors and antiviral agents
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, (2008/06/13)
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment
Pyrone derivatives as protease inhibitors and antiviral agents
-
, (2008/06/13)
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment
A Topliss tree analysis of the HIV-protease inhibitory activity of 6- phenyl-4-hydroxy-pyran-2-ones
Steinbaugh,Hamilton,Prasad,Para,Tummino,Ferguson,Lunney,Blankley
, p. 1099 - 1104 (2007/10/03)
In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made.
