170916-59-3

Upstream product

• 14064-10-9 diethyl 2-chloromalonate 
• 6262-87-9 2-isopropylbenzenethiol 

Downstream Products

• 178875-59-7 3-[4-Hydroxy-5-(2-isopropyl-phenylsulfanyl)-6-oxo-6H-pyran-2-yl]-benzoic acid ethyl ester 
• 170914-43-9 4-[4-Hydroxy-5-[(2-isopropylphenyl)thio]-6-oxo-6H-pyran-2-yl]benzoic acid ethyl ester 
• 178875-62-2 2-Hydroxy-5-[4-hydroxy-5-(2-isopropyl-phenylsulfanyl)-6-oxo-6H-pyran-2-yl]-benzoic acid ethyl ester 
• 178875-55-3 4-[4-Hydroxy-5-(2-isopropyl-phenylsulfanyl)-6-oxo-6H-pyran-2-yl]-benzonitrile 
• 178875-63-3 2-Hydroxy-5-[4-hydroxy-5-(2-isopropyl-phenylsulfanyl)-6-oxo-6H-pyran-2-yl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

A Topliss tree analysis of the HIV-protease inhibitory activity of 6- phenyl-4-hydroxy-pyran-2-ones

In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made.