170936-31-9Relevant academic research and scientific papers
(Dipropylamino)-tetrahydronaphthofurans: Centrally acting serotonin agonists and dopamine agonists-antagonists
Stjernloef, Peter,Lin, Chiu-Hong,Sonesson, Clas,Svensson, Kjell,Smith, Martin W.
, p. 2759 - 2764 (1997)
CNS-active aminotetralins containing phenolic moieties were transformed in a simple two-step procedure to the corresponding benzofurans. The compounds were tested in in vitro binding studies at serotonin 5-HT(1A) and 5-HT2 and dopamine D2, D3 and D4 receptors. These studies revealed that the furan homologs showed overall lower affinities than the phenol counterparts. This was also reflected that the furan homologs showed overall lower affinities than the phenol counterparts. This was reflected in vivo in biochemical studies. The benzofuran compounds retained most of the agonist/antagonist activities but with lower potency.
Aminoalcohols II: Preparation of Enantiomerically Pure Pharmacologically Active β-Aminoalcohols
Noe, C. R.,Knollmueller, M.,Gaertner, P.,Fleischhacker, W.,Katikarides, E.
, p. 481 - 494 (2007/10/02)
A synthesis of β-aminoalcohols is described starting from racemic or enantiomerically pure α-hydroxynitriles which were O-protected using enantiomerically pure acetal type protective groups.Reduction with lithium aluminium hydride yielded O-protected β-aminoalcohols.Whenever diastereomeric O-protected cyanohydrins could not be separated, the mixture was reduced and the resulting O-protected aminoalcohols were separated.Removal of the protective group using hydrogen chloride and methanol yielded enantiomerically pure β-aminoalcohols or their corresponding hydrochlorides. - Keywords: 1,2-Amino-alcohols, enantiomerically pure; Lithium aluminium hydride reduction
