170938-55-3

Basic information

• Product Name: 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole
• Synonyms: 1H-imidazole, 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-
• CAS NO: 170938-55-3
• Molecular Formula: C₂₀H₁₆FN₃
• Molecular Weight: 317.3595
• Mol File: 170938-55-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 536.3°C at 760 mmHg
• Flash Point: 278.1°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.92E-11mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole(170938-55-3)
• EPA Substance Registry System: 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole(170938-55-3)

Safety Data

• Hazardous Substances Data: 170938-55-3(Hazardous Substances Data)

Usage

General Description

1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole is a chemical compound with a complex structure that includes a fluorophenyl group, a phenyl-1H-pyrrol-3-yl group, and an imidazole ring. 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole is often used in medicinal chemistry and drug development due to its potential pharmacological properties. The presence of the fluorophenyl and phenyl-1H-pyrrol-3-yl groups suggests that it may have effects on the central nervous system, while the imidazole ring indicates potential biological activity as an antifungal, antibacterial, or antiparasitic agent. Overall, 1-[(4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methyl]-1H-imidazole is a versatile compound with potential applications in various fields, particularly in the development of new pharmaceuticals.

Upstream product

• 170939-10-3 (4-fluorophenyl)(4-phenyl-1H-pyrrol-3-yl)methanone 
• 22966-25-2 (E)-1-(4-fluorophenyl)-3-phenyl-2-propen-1-one 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

Antifungal agents. 9. 3-Aryl-4-[α-(1H-imidazol-1-yl)arylmethyl]pyrroles: A new class of potent anti-Candida agents

A new class of potent antifungal agents, namely, 3-aryl-4-[α-(1H- imidazol-1-yl)arylmethyl]-pyrroles, is described. These compounds are related to bifonazole and pyrrolnitrin, two compounds belonging to the class of antimycotic drugs. The synthesis of the title pyrroles has been performed starting from 1,3-diaryl-2-propen-1-ones, which were reacted with tosylmethyl isocyanide to give 3-aroyl-4-arylpyrroles. Reduction of the resulting compounds by lithium aluminum hydride furnished the related alcohols, which were treated with 1,1'-carbonyldiimidazole to afford the required imidazole derivatives. Forty-four new pyrroles which incorporate an (arylmethyl)imidazole moiety in the 3-arylpyrrole structure were prepared by the above procedure and tested in vitro against Candida albicans and Candida spp. Among test compounds, 10 were found to be highly active against C. albicans. The most active derivative (27) was twice as potent (MIC90) as bifonazole, and its activity was 4 times greater than those of miconazole and ketoconazole. The other nine compounds showed antifungal activity of the same order of that of bifonazole and were ca. 2 times as active as miconazole and ketoconazole. Derivatives 21 and 27 tested in vivo against C. albicans A170 were shown to be highly effective in rabbit skin candidosis. Pharmacological studies on compounds 27 and other related pyrroles (19, 35, 36, 38, 39, and 49) are in progress to select one of them as a potential candidate for clinical experiments.