170938-97-3

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 

Downstream Products

• 1110673-80-7 N₁-phenyl-3-(2,4-dichlorophenyl)-5-(4-chlorophenyl)-2-pyrazoline 
• 1354917-35-3 4-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine 

Relevant academic research and scientific papers

A novel series of 3,4-disubstituted dihydropyrazoles: Synthesis and evaluation for MAO enzyme inhibition

In this study, the authors have designed and synthesized a novel series of 3-acyl-4-aryl-4,5-dihydropyrazoles, with the aim to obtain new potential scaffolds for the inhibition of both isoforms of monoamine oxidase.

Synthesis, molecular docking and biological evaluation of some novel heterocyclic derivatives

ASERIES of heterocyclic derivatives 2-15 including pyrimidinone and pyrimidine thione rings were synthesized by using chalcones 1a-c as starting materials. Treatment of compound 1a with hydrogen peroxide afforded the corresponding epoxide 2, which afford

Anti-bacterial and anti-leishmanial studies of 4, 6-diarylpyrimidin-2- amines

Seven new chalcones along with nine already reported ones were synthesized from aryl aldehydes and substituted acetophenones by Claisen-Schmidt condensation. Each chalcone was treated with guanidine hydrochloride followed by oxidation with H2O

Focus on the synthesis and reactions of some new pyridine carbonitrile derivatives as antimicrobial and antioxidant agents

3-(4-CHLOROPHENYL)-I-(2,4-dichlorophenyl)-propen-l-onc (1) was prepared and reacted with active methylene compound, ethyl cyanoacetate in the presence of ammonium acetate to give the corresponding pyridine carbonitrilc (2). The behavior of compound 2 towards phosphorous pentasulfide, phosphorous oxychloride and some acyclic-sugars has been investigated and afforded compounds 3, 4 and 5a-d, respectively. The thioxo-pyridine carbonilrile (3) reacted with different halo compounds namely: methyl iodide, ethyl chloroacetate, some acyclic sugars to afford 6, 7 and 8a-c, respectively. Treatment of compound 3 with acryloiiitrile afforded compound 9. Reaction of the thiosulfanyl 6 with hydrazine hydrate gave the hydrazino derivative 10 while reaction of 7 with the same reagents gave the acid hydrazide 11. Also, compound 4 reacted with different nuclcophiles to afford compounds 10, 12-14. Condensation of compound 10 with ethyl acetoacetate, acetyl acetone, acetic anhydride, p-chlorobcnzaldehyde afforded compounds 15-18, respectively. Moreover, compound 10 reacted with carbon disulfide to afford compound 19. Finally, condensation of compound 10 with aldehydo-sugar namely: D-glucose gave the corresponding acyclic nucleoside 20. Furthermore, biological evaluation of some prepared compounds has been assessed and some of them revealed promising antimicrobial and antioxidant activity.

Synthesis of some benzothiazepins and their antimicrobial activities

A series of 2-[(substitutedphenyl)-4-(substitutedphenyl)]-3,3-dihydro substituted-1,5-benzothiazepin 3 has been synthesized starting from acetophenones. The compounds are characterized and screened for their antimicrobial activities.