170939-06-7

Upstream product

• 22106-37-2 4-(1H-pyrrol-1-yl)acetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 99-92-3 p-aminobenzophenone 

Relevant academic research and scientific papers

Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties

We report here the synthesis, antibacterial and antitubercular evaluation of 61 novel pyrrolyl derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties. Molecular docking was carried out on enoyl ACP reductase from Mycobacterium tuberculsosi

Pyrrolyl pyrazoline carbaldehydes as Enoyl-ACP reductase inhibitors: Design, synthesis and antitubercular activity

Introduction: In efforts to develop new antitubercular (anti-TB) compounds, herein we describe cytotoxic evaluation of 15 newly synthesized pyrrolyl pyrazoline carbaldehydes. Method & Materials: Surflex-Docking method was used to study binding modes of th

Synthesis of new pyrazolyl pyrrole derivatives as antitubercular agents

A series of pyrrole-containing biheterocyclic derivatives was synthesized, using substituted chalacone derivatives (4a-q) as a precursor, which were prepared by the reaction of substituted benzaldehyde (1a-q) with 4-(1H-pyrrol-1-yl)-acetophenone (2) in 40

Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro

Use of artemisinin based combination therapies (ACTs) is increasing in treatment of malaria. Their extensive and indiscriminate deployment will ultimately lead to selection of resistance. Thus, alternate ACTs are needed. We reported in vitro antimalarial